Breast Cancer Recearch Center, ACECR
Iranian Journal of Breast Diseases
1735-9406
14
4
2022
2
1
Emotion Focused Therapy Enduringly Reduces Depression and Increases Self-Compassion in Women with Breast Cancer: A Semi-Experimental Study
4
20
FA
Zahra
Salarirad
Ph.D. Student in Health Psychology, Department of Psychology, Faculty of Psychology and Educational Science, Central Tehran Branch, Islamic Azad University, Tehran, Iran
Lida
Leilabadi
Department of Psychology, Faculty of Psychology and Educational Science, Central Tehran Branch, Islamic Azad University, Tehran, Iran
Adis
Kraskian Mujembari
Department of Psychology, Faculty of Psychology and Educational Science, Karaj Branch, Islamic Azad University, Karaj, Iran
Mahdieh
Salehi
Department of Psychology, Faculty of Psychology and Educational Science, Central Tehran Branch, Islamic Azad University, Tehran, Iran
Introduction: Emotion-focused therapy (EFT) is designed to help patients identify and process their emotions. The aim of this study was to evaluate the effect of emotion-focused therapy on improving depression and self-compassion in women with breast cancer.
Methods: This was a quasi-experimental study with a pretest-posttest design with a control group and a 3-month follow-up. The sample consisted of 30 women with breast cancer in Tehran who had a depression score of >17 at screening and were selected via purposive sampling and randomly placed in experimental and control groups of 15. The experimental group underwent EFTover twelve 50-minute individual sessions according to the Greenberg emotion-focused therapy protocol. Research data were collected using the Beck Depression Inventory and the Self-compassion Scale before, after, and 3 months after the end of treatment. Data analysis was performed using repeated-measures two-way ANOVA.
Results: The experimental group scored significantly higher in self-compassion and lower in depression in the posttest compared with the pretest. In the follow-up assessment, depression scores were as low as the posttest levels, but self-compassion scores decreased relative to the posttest; however, they remained significantly above the pre-test levels. In the control group, both depression and self-compassion scores were stable over time.
Conclusion: EFT can be used as an appropriate intervention to reduce depression and increase self-compassion significantly and enduringly in women with breast cancer.
Breast Cancer Recearch Center, ACECR
Iranian Journal of Breast Diseases
1735-9406
14
4
2022
2
1
Evaluation of Salivary Level of Heat Shock Protein 70 in Patients with Breast Cancer
21
30
FA
Paria
Motahari
Department of Oral Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
Reza
Eghdam Zamiri
Department of Radiation Oncology, Tabriz University of Medical Sciences, Tabriz, Iran
Mohammadreza
Fatemi
Department of Oral Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
Introduction: Breast cancer is the most common cancer diagnosed among women worldwide. Increased molecular and genetic information about cancer has improved diagnostic, screening, and treatment methods for cancer. Heat shock protein 70 (HSP70) is overexpressed in breast cancer patients and involved in malignant properties of breast cancer. Due to the noninvasive nature of saliva collection and the fact that no study has been performed on salivary HSP70 levels in patients with breast cancer, the aim of this study was to evaluate the diagnostic value of salivary HSP70 in these patients.
Methods: Saliva samples from 45 patients with breast cancer and 45 age-matched healthy subjects were collected. Salivary HSP70 was measured with the enzyme-linked immunosorbent assay method. The results were analyzed using a Mann-Whitney test. The sensitivity, specificity, and diagnostic value of this protein were evaluated through the ROC curve and cutoff point determination. The software used in this study was SPSS 25, and a P value of less than 0.05 was considered significant.
Results: The mean salivary HSP70 level was 15.41 ± 8.82 ng/ml in patients compared with 15.03 ± 6.28 ng/ml in the control group (P > 0.05). Also, the area under the ROC curve was 0.497.
Conclusion: The results showed that salivary HSP70 levels were not significantly different between patients with breast cancer and healthy individuals, and according to the ROC curve, the salivary level of this protein has no diagnostic value in these patients.
Breast Cancer Recearch Center, ACECR
Iranian Journal of Breast Diseases
1735-9406
14
4
2022
2
1
Correlations of Diabetes and the Risk Factors with the Survival of Breast Cancer Patients
31
44
EN
Marjan
Sharifi Nasab
Faculty of Nursing and Midwifery, Sabzevar University of Medical Sciences, Sabzevar, Iran & Department of Nursing, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
Hamideh
Yazdimoghaddam
Department of Operating Room, Iranian Research Center on Healthy Aging, Faculty of Paramedics, Sabzevar University of Medical Sciences, Sabzevar, Iran
Seyedeh Tahereh
Mohaddess
Department of Hematology & Medical Oncology, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Mohammad Hasan
Rakhshani
Department of Biostatistics and epidemiology, Iranian Research Center on Health Aging, School of Public Health, Sabzevar University of Medical Sciences, Sabzevar, Iran
Introduction: Diabetes is associated with an increased risk of cancer. Because of the metastatic nature of cancer, the survival of women with breast cancer is decreasing despite receiving various treatments such as chemotherapy, radiotherapy, etc. The aim of this study was to investigate the relationship between diabetes and the risk factors related to the survival of breast cancer patients.
Methods: This was a descriptive-analytical study. Patients were selected via systematic random sampling and then divided into diabetic and nondiabetic groups. Then the 5-year survival rate of patients was were compared.
Results: The mean and median for survival were 9.95 and 13.00 years. The risk of death in breast cancer patients positive for estrogen receptor was significantly reduced compared with patients negative for estrogen receptor (HR, 0.314; 95% CI, 0.109–0.907; P = 0.03).
Conclusion: The results of the study indicate that the survival of breast cancer patients in diabetics is not significantly different from non-diabeticsUse of metformin and estrogen receptor positivity is associated with higher 5-year survival rates in women with breast cancer. Therefore, cancer screening programs in high-risk groups, especially in diabetic patients, and hyperglycemic control may affect survival time.
Breast Cancer Recearch Center, ACECR
Iranian Journal of Breast Diseases
1735-9406
14
4
2022
2
1
Inhibitory Effect of miRNA-145 on PD-L1 Expression in Breast Cancer Cell Line
45
61
FA
Sara
Hajibabaei
Department of Biology, School of Basic Science, Science and Research Branch, Islamic Azad University, Tehran, Iran
Fattah
Sotoodehnejadnematalahi
Department of Biology, School of Basic Science, Science and Research Branch, Islamic Azad University, Tehran, Iran
Nahid
Nafisi
Breast Surgery Department, Iran University of Medical Sciences, Tehran, Iran
Sirous
Zeinali
Molecular Medicine Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran
Masoumeh
Azizi
Molecular Medicine Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran
Introduction: PD-L1 is one of the most important immune control molecules in breast cancer and plays an important role in suppressing the immune system against tumor cells. Controlling the expression of PD-L1 at mRNA level using miRNA inhibitors could be helpful strategy for cancer treatment. In this study, considering the possible role of miR-145 as a tumor suppression in breast cancer, its involvement in reducing PD-L1 expression in breast cancer cell lines has been investigated.
Methods: First, the targeting of miRNA-145 on 3 'UTR of PD-L1 gene was confirmed using bioinformatics software and then by luciferase dual reporter assay. The expression level of miRNA-145 was measured in breast cancer cell lines compared to normal line. After transfection of miRNA-145 into breast cancer cell lines, qRT-PCR was used to evaluate the effect of miRNA-145 on PD-L1 expression.
Results: we showed that decreased expression of miRNA-145 in breast cancer cell lines was directly related to increased PD-L1 expression (r= -0.6175, P value₌0.0457). In addition, increased expression of miRNA-145 in breast cancer cell lines MDA-MB231, BT549 and MCF7 significantly reduced PD-L1 expression (1.938±0.212, 1.784±0.03 and 0.083±0.02 respectively).
Conclusion: Our findings suggest that miRNA-145, by targeting the PD1/PD-L1 pathway and reducing PD-L1 expression, may be a therapeutic agent to prevent the progression of breast cancer.
Breast Cancer Recearch Center, ACECR
Iranian Journal of Breast Diseases
1735-9406
14
4
2022
2
1
Factors Related to Breast Cancer Preventive Behaviors in Middle-aged Women: An Application of Protection Motivation Theory
62
74
FA
Zakieh Sadat
Hosseini
Department of Health Education and Health Promotion, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran & Department of Public Health, Neyshabur University of Medical Sciences, Neyshabur, Iran
Hamid
Tavakoli Ghouchani
Department of Health Education and Promotion, School of Health, North Khorasan University of Medical Sciences, Bojnord, Iran
Ali
Mehri
Department of Health Education, School of Health, Sabzevar University of Medical Sciences, Sabzevar, Iran
Hamid Reza
Mohaddes Hakak
Department of Health Education and Promotion, School of Health, North Khorasan University of Medical Sciences, Bojnord, Iran
Hossein
Lashkardoost
Department of Biostatistics and Epidemiology, School of Public Health, North Khorasan University of Medical Sciences, Bojnurd, Iran
Mehdi
Khankolabi
Department of Health Education and Promotion, School of Health, North Khorasan University of Medical Sciences, Bojnord, Iran
Zeinab
Jalambadani
Department of Public Health, Torbat Jam Faculty of Medical Sciences, Torbat Jam, Iran
Elahe
Salari
Department of Nursing, School of Nursing and Midwifery, North Khorasan University of Medical Sciences, Bojnourd, Iran
Introduction: Screening behaviors along with a healthy lifestyle and regular physical activity play an essential role in reducing mortality from breast cancer. The present study aimed to determine the factors associated with breast cancer–preventive behaviors based on the theory of protection motivation in women in Neyshabur city.
Methods: In this cross-sectional study, 325 women aged 30 to 69 years referred to Neyshabur health service centers were studied after enrolment through cluster sampling. The data collection tool was a researcher-made self-report questionnaire that had acceptable validity (face and content) and reliability (Cronbach’s alpha = 0.83). Data were analyzed using descriptive and analytical statistics with SPSS v19.
Results: Fifty-two percent of participants never had a breast self-examination before, and 72.6% had never been to a health center for a clinical breast examination. Only 6.8% of the participants had regular physical activity. All constructs of conservation motivation theory, except fear, were correlated with breast cancer-preventive behaviors. Perceived self-efficacy had the highest score, and perceived cost had the lowest score among protection motivation theory constructs. Regression analysis reflected that protection motivation, perceived severity, perceived rewards, and awareness were predictors of the adoption of breast cancer–preventive behaviors. Overall, these variables could predict 15.4% of behavioral change.
Conclusion: Theory-based educational planning to encourage women to adopt breast cancer-preventive behaviors, including a healthy lifestyle and screening behaviors, is essential.
Breast Cancer Recearch Center, ACECR
Iranian Journal of Breast Diseases
1735-9406
14
4
2022
2
1
Rapid Health Technology Assessment of Oncotype DX in Patients with Early-Stage Breast Cancer
75
93
FA
Farimah
Rahimi
Health Management and Economics Research Center, Isfahan University of Medical Science, Isfahan, Iran
Mehrdad
Zeinalian
Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Reza
Rezayatmand
Health Management and Economics Research Center, Isfahan University of Medical Science, Isfahan, Iran
Introduction: Breast cancer is the most common cancer in women. Patients are treated with chemotherapy initially, and if not chemically treated, the risk of recurrence of the disease increases yearly. Therefore, methods for identifying patients for whom chemotherapy would be most beneficial are very important. The Oncotype DX test is a prognostic assay that predicts the likelihood of breast cancer recurrence as well as the effectiveness of chemotherapy. Because of the novelty and the high cost of this test, the current study aims to determine its effectiveness and economic effects.
Methods: This study, based on rapid health technology assessment, explored the effectiveness and economic consequences of Oncotype DX compared with alternative methods in breast cancer patients. PubMed, Scopus, Web of Science, and Cochrane databases were searched, and only studies about the use of the Oncotype DX test in breast cancer were included.
Results: The results of the 32 relevant studies showed that the difference in outcomes was negligible across Oncotype DX and other gene expression profiling tests, but these differences were significant compared with standard treatment. Also, Oncotype DX testing would be cost-saving when used for patients under chemotherapy. However, using this test for all patients may not be cost-saving depending on the number of patients who switch from hormone therapy to chemotherapy and vice versa.
Conclusion: Although the results of this study are helpful for policymakers and therapists, it is better to make decisions based on the results of effectiveness and cost in Iran.