Breast Cancer Recearch Center, ACECR
Iranian Journal of Breast Diseases
1735-9406
15
1
2022
4
1
Evaluation of Factors Related to Short-Term and Long-Term Survival of Breast Cancer Patients by Mixture Cure Model
4
17
FA
Afsaneh
Fendereski
Department of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
Ebrahim
Hajizadeh
Department of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
Shahpar
Haghighat
Department of Breast Diseases, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
Aliakbar
Rasekhi
Department of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
Introduction: Breast cancer is the most common cancer among women. Today, with advancements in medical sciences, increasing the cure probability of patients as well as increasing survival time is an important goal of cancer treatment. Therefore, in this study, in addition to examining patients’ survival, we investigated the cure probability of breast cancer patients and its prognostic factors using the semiparametric mixture cure model.
Methods: This is a retrospective cohort study of 1310 breast cancer patients admitted to Motamed Cancer Institute from 1995 to 2013 and followed up until 2018. The Kaplan-Meier curve and a semiparametric mixture cure model were fitted to data. In this model, patients were divided into two categories of cured and uncured, then the cure rate and the survival rate of uncured patients were calculated, and related factors were identified.
Results: Of the 1310 women with breast cancer in the study, 235 (18.1%) cases died and others were censored. Based on the Kaplan-Meier curve, the cure rate was 68%, and the last death case was observed about 12 years after diagnosis. Obesity, lymph node involvement, and mastectomy were identified as risk factors for patients' long-term survival, while larger tumor size, more advanced stage of the disease, and lack of chemotherapy were risk factors for short-term survival.
Conclusion: These findings indicate that many prognostic factors for breast cancer are not only important when choosing a treatment strategy in the short term, but they also play an important role in the long-term to identifying high-risk patients and those who still need further follow-up.
Breast Cancer Recearch Center, ACECR
Iranian Journal of Breast Diseases
1735-9406
15
1
2022
4
1
The Effect of Eight Weeks Pilatese Training on Some of White Blood Cells in Breast Cancer Patients
18
32
EN
Roya
Soleimani
Department of Sport Sciences, School of Education and Psychology, Shiraz University, Shiraz, Iran
Maryam
Koushkie Jahromi
Department of Sport Sciences, School of Education and Psychology, Shiraz University, Shiraz, Iran
Amene
Mahmoodi
Department of Sport Sciences, School of Education and Psychology, Shiraz University, Shiraz, Iran
Javad
Nemati
Department of Sport Sciences, School of Education and Psychology, Shiraz University, Shiraz, Iran
Introduction: One of the recommended exercises for breast cancer patients is Pilates, which, although is useful in some aspects, but its effect on the immune system is not clear. The aim of this study was to evaluate the effect of eight weeks of Pilates exercises on immune factors in women with breast cancer.
Methods: Participants of the study included 30 breast cancer patients aged 30–57 years who participated in the study voluntarily and were randomly divided into two groups of exercise (n = 18) and control (n = 12). Finally, according to the exclusion criteria, participants were studied in two groups of exercise (n = 15) and control (n = 8). The exercise group performed Pilates training for eight weeks, three days a week, for 60 minutes per session. Blood samples were taken from the two groups at baseline and 48 hours after the exercise training.
Results: The variables in the two groups of exercise (n= 15, age: 40.66± 6.30 years, BMI: 26.67± 5.27 kg/m2) and control (n= 8, age: 49.12± 7.31± 31 years, BMI: 28.96± 4.03 kg/m2) were compared. The results showed that Pilates training had no significant effect on neutrophil at baseline (51.58± 5.77) and post intervention (56.75± 8.69) compared with the control group at baseline (53.87± 5.11) and post intervention (52.87± 3.22) (P= 0.19). Pilates training had no effect on Lymphocyte at baseline (40.25± 7.50) and post intervention (37.75± 10.04), compared with the control group at baseline (36.86± 6.74) and post intervention (37.87± 5.64), (P= 0.84). Also, Pilates training had no significant effect on the ratio of neutrophils to lymphocytes in the exercise group at baseline (1.34± 0.37) and post intervention (1.64± 0.59) compared to the control group at baseline (1.52± 0.40) and post intervention (1.42± 0.25) (P= 0.23).
Conclusion: Breast cancer patients can participate in Pilates exercises without any side effects on the immune system. Still, the intensity of these exercises may not have been enough to improve immune function.
Breast Cancer Recearch Center, ACECR
Iranian Journal of Breast Diseases
1735-9406
15
1
2022
4
1
Design and Evaluation of e-Learning Package for Breast Cancer Prevention for Iranian Women
33
45
FA
Najme
Nazeri
Lifestyle Medicine Department, Medical Laser Research Center, ACECR, Tehran, Iran & PhD Student at Department of Knowledge and Information Science, Management and Economics Faculty, Tarbiat Modares University, Tehran, Iran
Shahpar
Haghighat
Department of Quality of life, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
Atefeh
Jourabian
Department of Pediatric and Neonatal Nursing, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran
Sara
Dorri
Health Information Technology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Introduction: Given the high prevalence of breast cancer and its incidence and mortality worldwide, it seems that prevention is the best way to control it. The challenge facing e-learning is the production of appropriate, usable, and effective content. In this study, an electronic educational package titled “Breast Cancer Prevention” was designed and evaluated.
Methods: This research was conducted in three main phases: (1) preparation of educational content, (2) evaluation and localization of evidence-based content, and (3) evaluation from experts’ and end users’ point of view.
Results: The educational content in the field of early detection methods, risk factors, the role of nutrition in prevention, the role of physical activity in prevention, and the early signs of breast cancer were approved by experts with high validity. The evaluation of the electronic content in different formats produced by the target group also showed that the content scored above 4.3 of 5.
Conclusion: According to the evaluations of the training package, this package can be used as an acceptable product based on up-to-date scientific evidence in the field of breast cancer prevention.
Breast Cancer Recearch Center, ACECR
Iranian Journal of Breast Diseases
1735-9406
15
1
2022
4
1
The Clinical and Prognostic Significance of Triple-Negative Status Invasive Breast Cancer in a Sample of Iraqi Women
46
58
EN
Ahmed
Abd Ali Shihad
M.B.Ch.B, FICMS, Diwaniya Teaching, Hospital, Iraq
Bahaulddin
Adnan Yousif Alkamolei
M.B.Ch.B, FICMS, Diwaniya Teaching, Hospital, Iraq
Hawraa
Abdulkadhum Nasser
M.B.Ch.B, FICMS, Imam Al_Hussain Medical City, Iraq
Introduction: Triple-negative breast cancer (TNBC) is a type of breast cancer that is negative for estrogen receptor, progesterone receptor, and HER2. This study aimed to evaluate the clinical outcomes and short-term prognosis of this type of cancer compared with other subtypes of breast cancer.
Methods: A cross-sectional study was conducted on 108 women with invasive breast cancer. The patients were divided into a TNBC or a non-TNBC group. Multiple clinicopathological variables, diagnostic modality reports, progression-free survival, and overall survival were assessed.
Results: The results showed no statistically significant difference between the TNBC group and the non-TNBC group in age, BMI, or family history of breast cancer. In the TNBC group, compared with the non-TNBC group, the presence grade 3 tumor and lymphovascular invasion were significantly higher (P = 0.02 and P = 0.014, respectively). Progression-free survival rates in the TNBC and non-TNBC groups were 81.4% and 90.9%, and overall survival in the two groups were 93.8% and 93%, respectively.
Conclusion: There was a significant difference between the two groups in the form of histologic grade and presence of lymphovascular invasion. Non-significant differences in progression-free survival and overall survival between the two groups may be due to the short duration of follow-up.
Breast Cancer Recearch Center, ACECR
Iranian Journal of Breast Diseases
1735-9406
15
1
2022
4
1
The Relationship Between Metabolic Syndrome and Breast Cancer in Women Referred to Radiotherapy and Chemotherapy Clinics of Tohid Hospital in Sanandaj
59
70
FA
Milad
Tarimoradi
Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran
Ramyar
Rahimi Darehbagh
Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran
Media
Babahajiani
Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran
Bayazid
Ghaderi
Cancer and Immunology Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran & Liver and Digestive Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran
Introduction: Metabolic syndrome or insulin resistance syndrome is described as abdominal obesity, dyslipidemia, fasting blood sugar, and high blood pressure. This study aimed to investigate the relationship between metabolic syndrome and breast cancer.
Methods: This case-control study was performed on 222 women with cancer and non-cancer (breast cancer) (111 participants in each group) referred to Tohid and Besat Hospital in Sanandaj in 2014.
Results: The results showed that the prevalence of metabolic syndrome in people with and without breast cancer was 85 (76.6%) and 60 (54.1%), respectively, which was statistically significant.
Conclusion: The results showed that the criteria for defining metabolic syndrome increase cancer risk, especially breast cancer in women, and measures should be taken to reduce these risks in high-risk groups.
Breast Cancer Recearch Center, ACECR
Iranian Journal of Breast Diseases
1735-9406
15
1
2022
4
1
Evaluating the Toxicity of Doxorubicin-Silk Fibroin Nanoparticles and Its Effect on P53 Gene Expression in Breast Cancer Cell Line
71
86
FA
Shaghayegh
Vojdani Nejad Yazdi
Department of Biology, Science and Arts University, Yazd, Iran
Hadi
Zare-Zardini
Hematology and Oncology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Seyed Mohsen
Miresmaeili
Department of Biology, Science and Arts University, Yazd, Iran
Farzaneh
Fesahat
Reproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Introduction: The use of drug delivery systems can increase the effectiveness of chemotherapy and reduce its side effects in the treatment of breast cancer. This study aimed to evaluate the effect of doxorubicin-containing silk fibroin nanoparticles (NF-DOX) on P53 gene expression in breast cancer cell lines and to measure its toxicity in vitro.
Methods: NF-DOX was synthesized and characterized. The breast cancer cell line MCF-7 and normal HFF cell line were treated with different concentrations of NF-DOX, and its toxicity and relative expression of P53 were measured.
Results: Examination and characterization of the synthesized compound of NF-DOX indicated its nanometer dimension. The drug’s cytotoxic effect on MCF-7 cells was significantly greater compared with HFF cells and the control group (P < 0.001). The IC50 values (half-maximal inhibitory concentration) for MCF-7 and HFF cells treated with NF-DOX were 229 and 647 µg/ml, respectively. The relative gene expression levels of P53 in MCF-7 and HFF cell lines compared with the controls were measured as 27.09 ± 0.51 and 0.57 ± 0.07, respectively. The relative gene expression of P53 in MCF-7 and HFF cell lines showed a significant increase (P < 0.0001) and decrease (P < 0.0006) compared with controls, respectively.
Conclusion: Differential and significant changes in P53 gene expression in cell lines indicate that NF‑DOX may play an effective role in inhibition of breast cancer metastasis. The results showed a dose- and time-dependent anticancer effect of NF‑DOX, and it can be considered as a candidate for a new anticancer drug.
Breast Cancer Recearch Center, ACECR
Iranian Journal of Breast Diseases
1735-9406
15
1
2022
4
1
THE effectiveness of meaning-based existential therapy on anxiety and serum levels of tumor necrosis factor TNFα in women with breast cancer
87
102
FA
Maryam
Ahmadinasab
PhD Student in Health Psychology, Department of Health Psychology, Karaj Branch, Islamic Azad University, Karaj, Iran
Saied
Malihialzackerini
Department of Health Psychology, Karaj Branch, Islamic Azad University, Karaj, Iran
Fathollah
Mohaghegh
Department of Radiation Oncology, University of Medical Sciences, Arak, Iran
Sheida
Sodagar
Department of Health Psychology, Karaj Branch, Islamic Azad University, Karaj, Iran
Mehrdad
Sabet
Department of Psychology, Roodehen Branch, Islamic Azad University, Roodehen, Iran
Introduction: Diagnosing cancer can be a very anxious experience, and anxiety can disrupt immune system function. Tumor necrosis factor-alpha (TNFα) is an inflammatory cytokine that is associated with amplified tumor cell proliferation, higher malignancy, increased metastasis, and poor general prognosis for the patients who suffer from breast cancer.
Methods: This study is a randomized clinical trial with follow-up and control group. The experimental group underwent meaning-based existential intervention. Both groups were assessed by Beck Anxiety Questionnaire and serum levels of tumor necrosis factor before, after and three months after the intervention, and data were analyzed by repeated measures analysis of variance.
Results: The experimental group showed a decrease in anxiety scores and serum TNFα levels after receiving a psychotherapy program/interventions compared to the control group. The results show that the mean of TNFα was 47.10± 1.22 and the mean of anxiety was 21.75± 9.30 in the experimental group, while the mean of TNFα was 50.75± 1.71 and the mean of anxiety was 44.7± 12.27 in the control group, this reduction has also been observed in the follow-up phase (0.001≥ p).
Conclusion: Based on the findings, meaning-based existential psychotherapy can reduce anxiety and serum TNFα levels by reducing patients' anxiety and helping to give meaning to life again. Accordingly, this treatment can be used along with medical treatments.