Write your message
Volume 12, Issue 3 (Iranian Quarterly Journal of Breast Disease 2019)                   ijbd 2019, 12(3): 17-25 | Back to browse issues page


XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Sadeghipoor Vojdani F, Agha-Alinejad H, Molanouri Shamsi M, Soudi S, Khanchi S. The Effect of Interval Training on the Expression of Tumor Suppressor Gene, Systemic Inflammation, and Tumor Volume in Breast Cancer–Bearing BALB/c Mice. ijbd 2019; 12 (3) :17-25
URL: http://ijbd.ir/article-1-769-en.html
1- Physical Education & Sport Sciences Department, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran
2- Immunology Department, Favulty of Medical Sciences, Tarbiat Modares University, Tehran, Iran , halinejad@modares.ac.ir
3- Immunology Department, Favulty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
Abstract:   (4231 Views)
Introduction: E-cadherin is expressed in most normal epithelial tissues. Loss of E-cadherin can cause dedifferentiation and invasiveness in human carcinomas, leading E-cadherin to be classified as a tumor suppressor. Therefore, the aim of this study was to investigate the effect of interval training on the expression of tumor suppressor gene E-cadherin in breast cancer-bearing BALB/c mice.
Methods:  Twenty female BALB/c mice were purchased from the Pasteur Institute and transferred to the Animal Laboratory of Tarbiat Modares University and randomly divided into four groups of training-cancer-rest, training-cancer-training, rest-cancer-rest, and rest-cancer-training. Cancer was induced by subcutaneous injection of 4T1 cell line. The mice performed an average-intensity interval training for 10 weeks, 5 days per week. Forty-eight hours after the last exercise session, the mice were sacrificed to measure the research variables. Gene expression was investigated using real-time PCR. The Kruskal-Wallis test was used to determine the statistical differences between groups.
Results: There was a significant difference in the E-cadherin gene expression between the training-cancer-training and rest-cancer-rest groups (p = 0.03). This difference was also observed between the training-cancer-training and training-cancer-rest groups (p = 0.04).
Conclusion: Interval exercise training may influence the expression of major tumor suppressor genes and systemic inflammation involved in the development of metastasis and even reverse this process.
Full-Text [PDF 728 kb]   (1878 Downloads)    
Conclusion: Interval exercise training may influence the expression of major tumor suppressor genes and systemic inflammation involved in the development of metastasis and even reverse this process.

Type of Study: Research | Subject: Breast Diseases
Received: 2019/07/15 | Accepted: 2019/10/1 | Published: 2019/11/13

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Iranian Journal of Breast Diseases

Designed & Developed by: Yektaweb