TY - JOUR T1 - Association of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio with Pathologic Response to Neoadjuvant Chemotherapy in Nonmetastatic Advanced Breast Cancer Subtypes in Kerman TT - بررسی ارتباط نسبت نوتروفیل به لنفوسیت و نسبت پلاکت به لنفوسیت با پاسخ پاتولوژی به شیمی‌درمانی نئوادجوانت در انواع زیرگروه‌های سرطان پستان پیشرفته غیرمتاستاتیک بیماران مراجعه کننده به بیمارستان‌ها و درمانگاه‌های آموزشی شهر کرمان JF - Iran-J-of-Breast-Dis JO - Iran-J-of-Breast-Dis VL - 15 IS - 4 UR - http://ijbd.ir/article-1-974-en.html Y1 - 2023 SP - 33 EP - 50 KW - Platelet to Lymphocyte Ratio KW - Neoadjuvant Chemotherapy KW - Neutrophil to Lymphocyte Ratio KW - Breast Cancer N2 - Introduction: Researchers have increasingly focused their concentration on the prognostic part played by inflammatory indices, such as the neutrophil to lymphocyte ratio (NLR) and the platelet to lymphocyte ratio (PLR). In breast cancer, the therapeutic effect of neoadjuvant chemotherapy (differs in patients, and a higher response rate reflects a better outcome. Therefore, the purpose of this study was to assess the association of NLR and PLR with response to neoadjuvant chemotherapy in advanced nonmetastatic breast cancer Methods: This cross-sectional study was performed on 120 patients with nonmetastatic advanced breast cancer who were candidates for neoadjuvant chemotherapy. Data were collected using a checklist and Peripheral blood samples were evaluated for the calculation of the neutrophil to lymphocyte ratio (NLR) and the platelet to lymphocyte ratio (PLR). After completion of neoadjuvant chemotherapy and surgery, the response was evaluated based on the pathology report. chi-square test and logistic regression were also used for data analysis. Results: Patients with a PLR below 126.98 (n = 84) were categorized as having low PLR, and those with a PLR greater than 126.98 (n = 36) were categorized as having high PLR. The high-PLR group showed a significantly greater response to neoadjuvant chemotherapy than the low-PLR group (P = 0.01). NLR was not correlated to the response to neoadjuvant chemotherapy (P = 0.24). An inverse relationship was observed between PLR and tumor size after treatment (P = 0.01). No significant relationship was observed between PLR and age, node status, tumor grade, or Ki67 status. Multivariate analysis showed no significant relationship between ER, PR, or HER2 expression levels and NLR or PLR. Conclusion: PLR is a good prognostic marker for breast cancer, and patients with a higher PLR respond better to neoadjuvant chemotherapy. M3 10.30699/ijbd.15.4.33 ER -