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Volume 17, Issue 3 (Iranian Journal of Breast Diseases 2024)
ijbd 2024, 17(3): 4-15 |
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Ethics code: IR.IUMS.REC.1402.090
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Bahardoust M, Zenynali E, Majdolashrafi F, Goodarzy B, Khaleghian M, Tizmaghz A et al . Predictors of Recurrence Rate in Women with Idiopathic Granulomatous Mastitis: A Multicenter Retrospective Cohort Study. ijbd 2024; 17 (3) :4-15
URL: http://ijbd.ir/article-1-1107-en.html
URL: http://ijbd.ir/article-1-1107-en.html
Mansour Bahardoust1 
, Elahe Zenynali2 , Fatemeh Majdolashrafi1 , Babak Goodarzy2 , Mohsen Khaleghian3 , Adnan Tizmaghz * 4, Ali Tayebi5
, Elahe Zenynali2 , Fatemeh Majdolashrafi1 , Babak Goodarzy2 , Mohsen Khaleghian3 , Adnan Tizmaghz * 4, Ali Tayebi5
1- Department of Epidemiology, School of Public Health & Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2- Department of Medical Education, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
3- Department of General Surgery, School of Medicine, Rasool Akram Medical Complex, Iran University of Medical Sciences, Tehran, Iran
4- Firoozabadi Clinical Research Development Unit (F A CRD U) Iran University of Medical Sciences (IUMS), Tehran, Iran ,adnan_ti@yahoo.com
5- Firoozabadi Clinical Research Development Unit (F A CRD U) Iran University of Medical Sciences (IUMS), Tehran, Iran
2- Department of Medical Education, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
3- Department of General Surgery, School of Medicine, Rasool Akram Medical Complex, Iran University of Medical Sciences, Tehran, Iran
4- Firoozabadi Clinical Research Development Unit (F A CRD U) Iran University of Medical Sciences (IUMS), Tehran, Iran ,
5- Firoozabadi Clinical Research Development Unit (F A CRD U) Iran University of Medical Sciences (IUMS), Tehran, Iran
Abstract: (351 Views)
Introduction: Idiopathic granulomatous mastitis (IGM) is a rare breast disease that manifests in most cases at a young age and during breastfeeding. The rate of disease recurrence depends on various factors. The present study aimed to assess the risk factors of recurrence in IGM patients.
Methods: This retrospective multicenter cohort study was conducted on 66 female patients with a definitive diagnosis of IGM who were treated between 2020 and 2022 in medical centers affiliated with the Iran University of Medical Sciences. Demographic, clinical, treatment, and recurrence data of IGM were evaluated for all patients using a checklist. Patients were assigned to two groups based on recurrence. A multivariate Cox proportional hazards model was employed to investigate the recurrence risk factors.
Results: The mean age of participants was 32.8±7.6 years. Moreover, 97% of patients had a history of at least one pregnancy, and 81.8% had a history of breastfeeding. Pain and palpable lumps were the most common clinical symptoms, with rates of 69% and 66.7%, respectively. Recurrence occurred in 21.2% of cases. The multivariate analysis demonstrated that the level of prolactin (ng/mL) and the treatment method were significantly correlated with the risk of IGM recurrence. (P<0.05)
Conclusion: As evidenced by the results of this study, the risk of IGM recurrence was higher in patients with high prolactin levels. Surgical or minimally invasive treatment (abscess aspiration and drainage) may be associated with a lower recurrence rate.
Methods: This retrospective multicenter cohort study was conducted on 66 female patients with a definitive diagnosis of IGM who were treated between 2020 and 2022 in medical centers affiliated with the Iran University of Medical Sciences. Demographic, clinical, treatment, and recurrence data of IGM were evaluated for all patients using a checklist. Patients were assigned to two groups based on recurrence. A multivariate Cox proportional hazards model was employed to investigate the recurrence risk factors.
Results: The mean age of participants was 32.8±7.6 years. Moreover, 97% of patients had a history of at least one pregnancy, and 81.8% had a history of breastfeeding. Pain and palpable lumps were the most common clinical symptoms, with rates of 69% and 66.7%, respectively. Recurrence occurred in 21.2% of cases. The multivariate analysis demonstrated that the level of prolactin (ng/mL) and the treatment method were significantly correlated with the risk of IGM recurrence. (P<0.05)
Conclusion: As evidenced by the results of this study, the risk of IGM recurrence was higher in patients with high prolactin levels. Surgical or minimally invasive treatment (abscess aspiration and drainage) may be associated with a lower recurrence rate.
Type of Study: Research |
Subject:
prevention
Received: 2024/04/17 | Accepted: 2024/07/25 | Published: 2024/10/6
Received: 2024/04/17 | Accepted: 2024/07/25 | Published: 2024/10/6
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