Showing 14 results for Type of Study: review
Safa Najafi,
Volume 3, Issue 1 (3-2010)
Abstract
Ahmad Kaviani, Behnoud Baradaran, Morteza Noparast,
Volume 3, Issue 1 (3-2010)
Abstract
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Volume 3, Issue 3 (10-2010)
Abstract
Abdolreza Kazemi, Behjat Kalantari Khandni , ,
Volume 8, Issue 3 (12-2015)
Abstract
Introduction: Obesity through production of estrogen and Adipokines is risk factor for breast cancer. The aim of present study was to investigate the effect of aerobic training on serum Adiponectin and estradiol levels in women with breast cancer.
Methods: The present study was quasi-experimental study. To do this, fifty patients with breast cancer at stage 2 from Kerman with mean of 51.16 year, weight 72.48 kg and height 157.74 cm that chemotherapy courses were completed, randomly divided into two groups: training (n = 30) and control (n = 20). Training group performed endurance training for 8 weeks with intensity between 40 to 55 percent of target heart rate. Before and after the exercise protocol, blood samples were taken from both groups and serum levels of Adiponectin and estradiol were measured by ELISA via a Boster kit.
Results: Present study results showed Significant decreased in serum levels of estradiol (F=14.71 P=0.001) and significant increase in serum levels of Adiponectin (F=8.85 P=0.005) in the experimental group after 8 weeks aerobic training compare to control group.
Conclusion: Decreased estradiol without medical intervention that is aim of hormone therapy in breast cancer patients can show a positive effect of physical activity. It seems that Adiponectin is involved in decrease of estradiol levels through inhibition of cholesterol synthesis. Considering the findings, regular aerobic training is recommended for patients with breast cancer.
Vahid Farajivafa, Nasim Khosravi , Mahdieh Molanouri Shamsi, Hamid Agha-Alinejad,
Volume 12, Issue 4 (2-2020)
Abstract
Introduction: Heart rate variability (HRV) is negatively associated with mortality. Decrease in HRV is common in cancer patients. The association between HRV and general survival in cancer patients has made HRV a valuable biomarker for evaluation of the disease prognosis. Exercise is considered an interventional strategy to improve various outcomes in cancer patients. The present paper provides a descriptive review of the literature regarding the effect of exercise interventions on HRV in cancer patients.
Methods: A systematic search was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines in PubMed and Google Scholar, from inception since 1950 till October 15, 2018. The terms exercise, training, cancer, neoplasms, heart rate variability, and HRV were used in the search. Eligible studies were those trials using structured exercise intervention and having untrained adult cancer patients. Only English-language papers were included in the review.
Results: Eight studies were included in the review. Of the various HRV parameters, 2 in the time domain (SDNN and RMSSD) and 3 in the frequency domain (LF, HF, and LF/HF) were commonly reported in the studies. Exercise intervention increased SDNN, RMSSD, and HF in all the studies, although the difference did not reach statistical significance in some cases. The results regarding LF and LF/HF were not consistent.
Conclusion: In general, exercise intervention can improve HRV in cancer patients. It is suggested that SDNN, RMSSD, and HF parameters be used in the evaluation of exercise effects on HRV because these parameters a) have prognostic value and b) more suitably reflect the effects of exercise training in these patients.
Farimah Rahimi, Mehrdad Zeinalian, Reza Rezayatmand,
Volume 14, Issue 4 (2-2022)
Abstract
Introduction: Breast cancer is the most common cancer in women. Patients are treated with chemotherapy initially, and if not chemically treated, the risk of recurrence of the disease increases yearly. Therefore, methods for identifying patients for whom chemotherapy would be most beneficial are very important. The Oncotype DX test is a prognostic assay that predicts the likelihood of breast cancer recurrence as well as the effectiveness of chemotherapy. Because of the novelty and the high cost of this test, the current study aims to determine its effectiveness and economic effects.
Methods: This study, based on rapid health technology assessment, explored the effectiveness and economic consequences of Oncotype DX compared with alternative methods in breast cancer patients. PubMed, Scopus, Web of Science, and Cochrane databases were searched, and only studies about the use of the Oncotype DX test in breast cancer were included.
Results: The results of the 32 relevant studies showed that the difference in outcomes was negligible across Oncotype DX and other gene expression profiling tests, but these differences were significant compared with standard treatment. Also, Oncotype DX testing would be cost-saving when used for patients under chemotherapy. However, using this test for all patients may not be cost-saving depending on the number of patients who switch from hormone therapy to chemotherapy and vice versa.
Conclusion: Although the results of this study are helpful for policymakers and therapists, it is better to make decisions based on the results of effectiveness and cost in Iran.
Firoozeh Alavian, Saeedeh Ghiasvand,
Volume 15, Issue 4 (1-2023)
Abstract
Introduction: Diet is an important environmental risk factor for breast cancer. Grapes are one of the most abundant fruits in the world; they are a valuable source of active metabolic compounds that control the proliferation and growth of breast cancer cells.
Methods: The present narrative review is based on Persian and English papers published between 1996 and 2022. The papers were retrieved via an internet search on PubMed, Google Scholar, Science Direct, and Scopus databases using the keywords “cancer,” “breast,” “bioactive metabolites,” “Vitis vinifera,” and “grapes.”
Results: The findings of the investigations showed that the bioactive compounds of grapes, including resveratrol, terpenoids, oleanolic acid, catechins, proanthocyanidins, anthocyanins, anthocyanidins, carotenoids, and flavonols, have the capacity to reduce oxidative stress, inhibit DNA synthesis, stop the cell division cycle, induce apoptosis of cancer cells, interact with multiple signaling pathways involved in the creation or destruction of tumors. Because of these functions, these compounds are of specific interest in the prevention and treatment of breast cancer.
Conclusion: Antitumor activities of natural compounds found in grapes indicate their possible role in the treatment of breast cancer.
Dr Elmi Fatemeh, Dr Maryam Aghajanizadeh, Ali Ghanbari Motlagh, Dr Ahmad Mafi,
Volume 15, Issue 4 (1-2023)
Abstract
COVID-19 has affected several aspects of healthcare systems worldwide. While our understanding of the impact of cancer and its treatment on COVID-19 mortality is improving, there is still little known regarding the possible mechanisms by which COVID-19 might interfere with cancer cells, especially breast cancer. Several factors activated during COVID-19 have been implicated in tumorigenesis and the development of metastasis. Inflammation, hypoxia, reduced levels of angiotensin converting enzyme 2, elevated levels of Interleukin 6 and some other cytokines that are hallmarks of COVID-19 are capable of inducing tumor relapse and metastasis. Understanding the interaction between COVID-19 and breast cancer tumor cells is essential for evaluating the potential long-term risks of COVID-19 in the patients, and for scheduling necessary preventive, screening and therapeutic interventions.
Nasim Bozorgi, Soghra Khani, Zolaykha Karamelahi, Forouzan Elyasi,
Volume 16, Issue 2 (5-2023)
Abstract
Introduction: New changes in the health care system have made cancer care in home settings rather than in-patient situation. The diagnosis of breast cancer in a woman affects all family members and accordingly changes the duties of family members. Family involvement in this patient’s care may consequence better outcomes. Family caregivers can be unpaid family members who help the patient with physical care and the disease process, and they should know their roles to do it better. This study aimed to review family caregivers’ roles in the life of women with breast cancer.
Methods: Database search was done in google scholar, PubMed, science direct, Magiran, and SID. The keywords were Family Caregivers, Breast Cancer, and Role. Research articles published from 1990 till 2017 with the relevant topic were selected for this study. Overall 80 articles were searched and 42 were used.
Results: After reviewing these articles family caregivers’ roles were organized in three dimensions. 1) medical-instrumental roles such as screening, diagnosis, treatment, Physical care of the patient, and pain relieve 2) psychosocial roles such as decision making, encouraging and giving hope, emotional and spiritual support, and Strengthen relationships and 3) Roles related to finance such as life cost, providing treatment and care cost and following insurance claims.
Conclusion: Family caregivers of patients with breast cancer can learn specific roles to care for their family members or friends to have fewer side effects during caregiving.
Ali Khezrian, Ali Shojaeian,
Volume 16, Issue 4 (1-2024)
Abstract
Introduction: Breast cancer is among the main reasons for most cancer-associated loss of life in women worldwide. The use of autologous lipotransfer has become increasingly popular for breast reconstruction. With the emerging data on the efficacy of stromal vascular fraction (SVF) in oncological safety and survival rates, although many studies have focused on improving the preservation of fat graft volume with this material, questions regarding safety and efficacy still remain. The present study aimed to determine the advantages and disadvantages of SVF in fat grafting, especially in its preservation.
Materials and Methods: Our search was conducted on published research between 2000 and 2022 using several international databases, including Scopus, PubMed, Web of Science, and Google Scholar. We also reviewed additional evidence from relevant published articles.
Results: Although the SVF is easier to isolate than adipose-derived mesenchymal stem cells (ADSCs), it contains a heterogeneous mix of cells. The SVF may act through angiogenesis promotion by endothelial/progenitor cells and immunomodulation by ADSCs. The SVF-enhanced fat grafts improve volume retention in animal models. Although limited clinical data supports improved breast augmentation with SVF without increased cancer recurrence, optimal SVF isolation and cell ratios require further research.
Conclusion: Based on the obtained findings, although SVF shows promise to improve fat grafting outcomes in breast reconstruction, more clinical studies on oncologic safety and technical considerations are warranted.
Saghar Salehpour, Nasrin Saharkhiz, Sedigheh Hosseini, Samaneh Esmaeili, Nazanin Hajizadeh, Leila Majdi, Hasti Ziaee,
Volume 17, Issue 1 (3-2024)
Abstract
Introduction: Breast cancer is one of the most common malignancies in women. Cytotoxic chemotherapy or drugs exert a negative effect on fertility potential. Techniques,such as ovarian suppression, oocyte and embryo freezing, InVitro Maturation, and ovarian tissue freezing, are necessary to preserve fertility.
Methods: To conduct this study, a query was conducted on Persian and English sources databases as Scoupus, Google Scholar, Pub Med, and Science Direct during the last 24 years using the following keywords: breast cancer, infertility, fertility preservation, oocyte freezing, and embryo freezing.
Results: Based on the result15% to 25% of patients are young premenopausal women. Chemotherapy or radiation therapy can lead to infertility or early menopause. As suggested by evidence, the success rate of embryo freezing is much higher than oocyte freezing and In Vitro Maturation. Among the fertility preservation methods, ovarian tissue freezing and 3D bioprinting are in the laboratory research stage and have received much attention. Correct counseling and providing accurate information to patients and their timely referral have have a marked impact on improving their mental and physical condition and treating their underlying disease.
Conclusion: As evidence by the result of this study, early diagnosis of breast cancer and timely referral to a fertility specialist enable , breast cancer patients to maintain their fertility and experience their biological child after aggressive cancer treatments.
Maryam Moradi, Azin Niazi, Kowsar Hakami Shalamzari,
Volume 17, Issue 2 (5-2024)
Abstract
Background: Breast cancer is one of the most common malignancies in women in Iran, and sexual dysfunction is often observed in these patients.
Objectives: The present study aimed to systematically review the clinical trials to determine the effect of counseling-educational interventions on sexual issues of women with breast cancer in Iran.
Methods: In this systematic review, a query was conducted on databases, including Pubmed, WOS, SCOPUS, EMBASE, ClinicalTrials.gov, ProQuest Dissertations and Theses Global, Cochrane Library, CINAHL, SID, Magiran, and Irandoc up to Jan 2023. The keywords were sex, sexual counseling, sexual function, quality of sexual life, breast cancer, sexuality, education, and all possible combinations of these words with the Boolean operators of "OR" and "AND". The Cochran Group Risk of bias tool was used to evaluate the quality of articles.
Results: Finally, 10 studies (with a total sample size of 614 people) were systematically reviewed. Of these, 4 articles examined sexual counseling, 5 papers assessed sexual education, and 1 study compared sexual counseling and sexual education in patients. PLISSIT (P: Permission, LI: Limited Information, SS: Specific Suggestions, IT: Intensive Therapy) counseling, mindfulness, sexual psychology, commitment acceptance, sports counseling, couples training, and group counseling caused a significant difference in sexual variables between the intervention and control groups. Four-factor psychotherapy alone was not effective in increasing sexual assertiveness.
Conclusion: Based on the results, several types of counseling and educational approaches were effective in improving sexual problems and promoting sexual health in women with breast cancer in Iran; therefore, the widespread use of these methods is recommended.
Parsa Owliaee, Ensiyeh Jenabi, Soulmaz Rahbar,
Volume 17, Issue 3 (7-2024)
Abstract
Introduction: Lymphedema (LE) is a common complication following breast cancer (BC) treatment, characterized by lymphatic fluid accumulation in the interstitial tissue. The impact of air travel on LE risk in BC patients remains unclear. This study aimed to determine the potential role of air travel in increasing LE likelihood through a systematic review and meta-analysis.
Methods: A comprehensive search was conducted in international databases, including PubMed, Scopus, Science Direct, and Web of Science, until May 2023. The Newcastle-Ottawa Scale was used for quality assessment. A random effects model was applied for meta-analysis, with effect size estimated using odds ratios (OR) and 95% confidence intervals (CI).
Results: Among 3,480 BC patients from 8 studies, the pooled estimates showed no significant association between air travel and LE risk (OR=1.04, 95% CI=0.73 to 1.35). Significant heterogeneity was observed among studies (I2=74.8%, P=0.000).
Conclusion: The results demonstrate that air travel is not a significant risk factor for LE in patients treated for BC. These findings help alleviate concerns about air travel among BC survivors and improve their quality of life.
Farkhondeh Hasannejad, Ahmad Fazilat, Keivan Majidzadeh,
Volume 17, Issue 3 (7-2024)
Abstract
Introduction: Liquid biopsy is a novel diagnostic tool that investigates biological biomarkers within the blood and other body liquids in order to provide information about the genetics of the tumor and its treatment response. The current review study aimed to highlight the role of liquid biopsy in breast cancer and precision medicine.
Methods: In the current review study, we attempted to evaluate the recent innovations in breast cancer diagnosis by investigating liquid biopsy biomarkers in related databases, including Scopus, Web of Science, PubMed, and Google Scholar, from 2018 to 2024.
Results: The assessment of the published articles in this field revealed that the applications of biomarkers in liquid biopsy have a significant role in personalized medicines, highlighting their reliability for use in personalized medicine.
Conclusion: The liquid biopsy biomarkers seem to be a promising approach in breast cancer early detection and remarkable reduction of mortality caused by this disease in the near future.
