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Inhibitory Effect of miRNA-145 on PD-L1 Expression in Breast Cancer Cell Line
Sara Hajibabaei, Fattah Sotoodehnejadnematalahi, Nahid Nafisi, Sirous Zeinali, Masoumeh Azizi,
Volume 14, Issue 4 (Iranian Journal of Breast Disease 2022)
Abstract
Introduction: PD-L1 is one of the most important immune control molecules in breast cancer and plays an important role in suppressing the immune system against tumor cells. Controlling the expression of PD-L1 at mRNA level using miRNA inhibitors could be helpful strategy for cancer treatment. In this study, considering the possible role of miR-145 as a tumor suppression in breast cancer, its involvement in reducing PD-L1 expression in breast cancer cell lines has been investigated.
Methods: First, the targeting of miRNA-145 on 3 'UTR of PD-L1 gene was confirmed using bioinformatics software and then by luciferase dual reporter assay. The expression level of miRNA-145 was measured in breast cancer cell lines compared to normal line. After transfection of miRNA-145 into breast cancer cell lines, qRT-PCR was used to evaluate the effect of miRNA-145 on PD-L1 expression.
Results: we showed that decreased expression of miRNA-145 in breast cancer cell lines was directly related to increased PD-L1 expression (r= -0.6175, P value₌0.0457). In addition, increased expression of miRNA-145 in breast cancer cell lines MDA-MB231, BT549 and MCF7 significantly reduced PD-L1 expression (1.938±0.212, 1.784±0.03 and 0.083±0.02 respectively).
Conclusion: Our findings suggest that miRNA-145, by targeting the PD1/PD-L1 pathway and reducing PD-L1 expression, may be a therapeutic agent to prevent the progression of breast cancer.

TRIM14 and TRIM29 as potential tumor markers for breast cancer diagnosis
Mohammadreza Roshanazadeh, Mojtaba Rashidi, Arash Sanaei, Hossein Azizi Dariuni, Amirnader Emami Razavi, Maryam Adelipour,
Volume 16, Issue 4 (Iranian Journal of Breast Diseases 2024)
Abstract
Introduction: Various members of the Tripartite-motif protein family contribute to different types of cancer, although the role of these factors in breast cancer is unclear. TRIM14 and TRIM29 have been reported to be overexpressed and play oncogenic roles in specific cancers.
Methods: A total of 40 pairs of tumor tissues and adjacent normal tissues of breast cancer patients were obtained. Relative gene expression of TRIM14 and TRIM29 were determined through quantitative reverse transcriptase polymerase chain reaction (qRT-PCR)  using specific primers.
Results: TRIM14 and TRIM29 were both overexpressed in breast tumor samples. The expression of TRIM14 was associated with tumor size, stage, and invasiveness. Nonetheless, no association was found between TRIM14 and the grade of the tumor. Also, TRIM29 gene expression was positively correlated with tumor size, stage, grade, and invasiveness. No correlation was found between the expression of TRIM14 and TRIM29.
Conclusion: Based on our results, we propose TRIM14 and TRIM29 as potential tumor markers in breast cancer.

Role of anxiety, depression, personality traits, social support, and spiritual well-being in prediction of personal growth in patients with breast cancer
Mohammad Golparvar Azizi, Daryush Moslemi, Farzan Kheirkhah, Hemmat Gholinia, Seyedmohsen Jafari, Ehsan Jalalian Ehsan Jalalian, Mahbobeh Faramarzi,
Volume 17, Issue 4 (Iranian Journal of Breast Diseases 2025)
Abstract
Introduction: The present study aimed to determine the frequency of post-traumatic growth (PTG) and to evaluate the roles of anxiety, depression, social support, and spiritual well-being in predicting PTG among patients with breast cancer (BC).
Methods: In a cross-sectional study, 197 BC patients completed several questionnaires, including the post-traumatic growth inventory (PTGI), the hospital anxiety and depression scale (HADS), the NEO five-factor inventory (NEO-FFI), the perceived social support scale (PSS), and a measure of spiritual well-being.
Results: The spiritual well-being (ß=0.290, 95% CI: 0.173-0.749, P<0.001), conscientiousness (ß=0.234, 95% CI: 0.175-0.573, P=0.001), and extraversion (ß=0.118, 95% CI: 0.103-0.419, P=0.005) were identified as positive predictors of PTG among the patients. In contrast, total social support and its subscales and three personality traits (neuroticism, openness to experience, and agreeableness) were not associated with PTG in this population.
Conclusion: Breast cancer patients with a specific psychological profile may be more likely to experience personal growth when confronted with their illness.

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