Write your message

Search published articles


Showing 2 results for Darzi

Mohammad Darzi, Asiye Olfat Bakhsh, Saeid Gorgin, Farid Oveisi, Esmat Hashemi, Nasrin Alavi,
Volume 9, Issue 2 (Iranian Quarterly Journal of Breast Diseases 2016)
Abstract

Abstract

Introduction: Breast Cancer is one of the common cancers in Iran. Each Prediagnosis of that can survive women from different risks. The aim of this research is classifying imbalanced dataset for detecting normal vs. abnormal women who came to ACECR Breast Cancer Clinic. Imbalanced datasets are one of the main challenges for designing medical decision support system. So, in this article, imbalanced data classification was addressed via data level solutions.

Methods: In this research for classifying of 918 women’ breast situation, the “AdaBoost.M1”, “K-nearest neighbor”, and “probabilistic neural network” as triple algorithms were used. Because of facing with imbalanced dataset, for solving that, “random over sampling”, “Random under sampling”, and “Synthetic Minority Over-sampling Technique” were used as 3 re-sampling methods. So, Mat lab and R as software tools were used for implementing of methods and algorithms. Also, the values of 60 features that extracted from women’s historical and physical exam forms were used as input data in triple algorithms. Finally, “precision” and “F-Measure” as two criteria were used for evaluating in test state of triple algorithms.

Results: Based on “precision” and “F-Measure” as two useful criteria, the best performance of this research’s classification algorithms were through dataset that generated by Synthetic Minority Over-sampling Technique. So, the performance of “AdaBoost.M1”, “K-nearest neighbor”, and “probabilistic neural network” for classification of that dataset based on “precision” and “F-Measure” were “93.5,93.6”, “79.5,87.7”,and “86,91.9”respectively.

Conclusion: There are different methods for solving imbalanced datasets problem through classification of that. Re-Sampling is one of the popular data level methods. Through 3 re-sampling methods, the best classification algorithm performance belongs datasets that generated by “Synthetic Minority Over-sampling Technique”, So among triple algorithms and four datasets that were used in this research and the based on “precision” and “F-Measure”, AdaBoost.M1 had the best performance in classification.


Mohammad Darzi, Saeid Gorgin, Keivan Majidzadeh-A, Rezvan Esmaeili,
Volume 14, Issue 1 (Iranian Journal of Breast Disease 2021)
Abstract

Introduction: HER2-enriched subtype of breast cancer has a worse prognosis than luminal subtypes. Recently, the discovery of targeted therapies in other groups of breast cancer has increased patient survival. The aim of this study was to identify genes that affect the overall survival of this group of patients based on a systems biology approach.
Methods: Gene expression data and clinical information on 58 patients with HER2-enriched cancer were downloaded from The Cancer Genome Atlas (TCGA). Co-expression modules were identified using the weighted gene co-expression network analysis (WGCNA). The Cox regression was used to determine the modules that had a significant relationship with the overall survival (OS) endpoint. Single-gene survival analysis was performed within the selected module. Finally, functional annotation to explore the significance of genes was performed using the Database for Annotation, Visualization, and Integrated Discovery (DAVID).
Results: Of the six identified co-expression modules, two had significantly poor prognoses. Single-gene survival analysis showed that 39% of genes in the selected modules were identified as significant. The genes were mainly related to the biological pathways such as Ubiquitin-mediated proteolysis and RNA degradation. CHAMP1, PPP1R26, PRRC2B, KANSL3, and ANAPC2 were identified as the 5 most important genes associated with reduced OS, in order of significance.
Conclusion: The systems biology approach can provide appropriate results relate to patient survival analysis. In this study, some genes were identified to be used as prognostic biomarkers in experimental studies related to the OS in the HER2-enriched subgroup. These genes can be considered potential candidates for therapeutic targets in this group of patients.


Page 1 from 1     

© 2025 CC BY-NC 4.0 | Iranian Journal of Breast Diseases

Designed & Developed by: Yektaweb