Showing 12 results for Sari
Esmat Alsadat Hashemi, Shahpar Haghighat, Mandana Ebrahimi, Asieh Olfatbakhsh, Parisa Mokhtari Hesari, Nasrinosadat Alavi, Laila Haydari, Hoda Tafazoli, Reza Mahdizadeh,
Volume 7, Issue 3 (Iranian Quarterly Journal of Breast Diseases 2014)
Abstract
Hoda Tafazzoli Harandi, Asiyeh Olfatbakhsh, Safa Najjar Najafi, Parisa Hosseinpour, Parisa Mokhtari Hesari, Esmat Alsadat Hashemi,
Volume 8, Issue 1 (Iranian Quarterly Journal of Breast Disease 2015)
Abstract
Akram Sajadian, Leila Hydary, Parisa Mokhtari Hesari,
Volume 8, Issue 2 (Iranian Quarterly of Breast Diseases 2015)
Abstract
Arezo Baktashian, Parisa Mokhtari Hesari , Mandana Ebrahimi, Safa Najar Najafi, Mahdi Rajabi,
Volume 8, Issue 4 (Iranian Quarterly Journal of Breast Diseases 2016)
Abstract
Fatemeh Khansari, Yasaman Saeedinejad, Azam Raoofi, Ehsan Shamsi Gooshki,
Volume 9, Issue 3 (Iranian Quarterly Journal of Breast Diseases 2016)
Abstract
Abstract
Introduction: Breast cancer is the most common cancer among women around the world, and the survival rate for patients greatly depends on their quality of life, which is in turn determined by their psychological experiences. The present study thus focuses on investigating psychological experiences among women with breast cancer.
Methods: This research is a content analysis qualitative study, based on semi-open and semi-structured interviews. The participants comprised of 15 patients with breast cancer, undergoing chemotherapy or follow-up treatments after their mastectomy, who had visited the Breast Cancer Research Center of the Academic Center for Education, Culture and Research (BCRC, ACECR) at the time of the research. None of the patients had distant metastasis and the disease was controlled. We have selected this group of patients because they are passing through the critical stage of facing with the bad news, spending many levels of their disease treatment, and achieving stability in the disease situation. After permission, the participants were interviewed with the open and unbiased questions in a relaxed atmosphere away from confounding factors and in an empty room of the clinic. The interview with each participant lasted 30 minutes and the participants orally allowed us to record the interview. The results were analyzed after several reviewing the transcript of the interview.
Results: The participants were 36 to 72 years old, and their education backgrounds ranged from illiteracy to bachelor's degree. All patients were married and had 1 to 3 children. After being diagnosed with breast cancer, some patients felt anger or sadness, and they generally emphasized on the necessity of emotional supports from their families to face the diagnosis results. Some participants did not view cancer as a disaster, and a majority of them did not wish they had not been affected with by cancer, while most of them contemplated about their death every night.
Conclusion: The results of the study depicted that while most patients experienced anger or sadness when they were informed about their cancer diagnosis, they had accepted the disease and its side effects through time, in a manner that most patients had coped with dramatic changes in their body image as a result of mastectomy, and did not recall it as a negative experience. It seemed that time could gradually change psychological experiences among cancerous patients.
Asiie Olfatbakhsh, Shahpar Haghighat, Mansoureh Khani, Toktam Beheshtian, Nasrin Alavi, Fatemeh Sari, Parisa Hosseinpour,
Volume 10, Issue 2 (Iranian Quarterly Journal of Breast Diseases 2017)
Abstract
Introduction: The status of the axillary lymph node is the most important factor in determining the prognosis of breast cancer. The aim of this study was to evaluate the sensitivity and specificity of Axillary Ultrasound (AUS) in the diagnosis of lymph node involvement in breast cancer patients referred to the Breast Cancer Research Center (BCRC) between March 2015 and Aug 2016.
Methods: Through a cross sectional study, all patients with a diagnosis of non-metastatic breast cancer with Stage I, II, IIIA and no chemotherapy before surgery were evaluated. The results of AUS and pathology after surgery were collected and analyzed using SPSS based on sensitivity and specificity formula.
Results: Of a total of 140 patients, the average age was 48.87 and the mean size of masses was 2.31 cm (0.4 -10 cm). Physical examination was positive in %14.6 of patients, positive AUS in %28.6 and pathologic axillary involvement in %39.2 of the patients. Sensitivity, specificity, PPV and NPV of AUS in diagnosing lymph node involvement were %55.5, %88.3, %75 and %76 respectively. Sensitivity, specificity, PPV and NPV of clinical examination were %31.48, %97.67, %89.4 and 69.4. The combination of positive AUS and physical examination were along with pathologic axillary involvement in %92.3 of patients. False positivity and false negativity of AUS were %11.6 and %17.1 in all.
Conclusions: The sensitivity and specificity of AUS in our patients is the same as the results of other countries. Clinical examination alone has a high false negative and low sensitivity, however AUS in addition to physical examination has higher sensitivity which could predict axillary involvement and lead to axillary dissection without sentinel node biopsy. Negative AUS has about %24 false negativity and SLNB could not be omitted until the results of trials would be published.
Esmat Hashemi, Shahpar Haghighat, Aseie Olfatbakhsh, Toktam Beheshtian, Fateme Sari, Akram Sajadian,
Volume 10, Issue 4 (Iranian Quarterly Journal of Breast Disease 2018)
Abstract
Abstract
Introduction: The increasing use of percutaneous imaging guided core needle biopsy (CNB) has reduced the application of excisional biopsy for assessment of breast lesions. Most often, lesions are reported as benign and sometimes as precancerous. In these cases, it is possible that the lesion is upgraded to malignant after excisional biopsy. This study aimed to evaluate upgrading rate in these lesions and the related factors.
Methods: We conducted a retrospective study of medical records of patients who received CNB in the radiology department of Iranian Breast Cancer Research Center between March 2014 and March 2017, were reported as Atypical Ductal Hyperplasia (ADH), Sclerosing Adenosis (SA), Flat Epithelial Atypia (FEA) Papillary Lesion (PL).
Results: A total of 208 patients had a diagnosis of precancerous lesions and entered the study. The patients’ mean age was 44.6 years (range: 22–61 years). The highest upgrading rate was in papillary lesions (20.4%) and atypical ductal hyperplasia (25%) while this rate was zero in sclerosing adenosis and flat epithelial atypia lesions. Data analysis indicate the significant correlation of tumor size and age with upgrade rate (p= 0.001 and p= 0.038, respectively).
Conclusion: Our study showed that upgrading rate increases with increasing age and tumor size. This rate is much higher in PL and ADH as compared to SA and FEA. Therefore, it is recommended that the tumor be excised in older patients and larger tumors to prevent cancer. In order to achieve more accurate results, specific studies for each lesion are required.
Asiie Olfatbakhsh, Ahmad Kaviani, Shahpar Haghighat, Esmat Hashemi, Hoda Tafazzoli Harandi , Fatemeh Sari,
Volume 11, Issue 2 (Iranian Quarterly Journal of Breast Disease 2018)
Abstract
Introduction: Different clinical trials showed that survival of Breast Conserving Surgery (BCS) and mastectomy is the same. However change in the appearance of a woman cause psychological trauma and could affect her quality of life. The aim of this study was to compare BCS and post-mastectomy reconstruction by prosthesis in terms of satisfaction and body image (BI) in Breast Cancer Research Center and Imam Khomeini Hospital.
Methods: Breast cancer patients in stage 0, I, II who completed their treatment at least 3 months ago were included since august 2016 till October 2017. The Persian version of the BICI (Body Image Concern Inventory) questionnaire was used and Patients’ satisfaction was evaluated by scoring and also four-scale answers. The mean score of outcomes were measured by SPSS software and correlation between demographic variables like age and marital status and outcomes were analyzed by non-parametric Kruskal-Wallis& Mann-Whitney.
Results: A total of 70 patients with BCS cases and 43 patients with prosthetic reconstruction were enrolled. The mean follow up time was 43.5 months (3-288) and the mean age was 44.3. There were no significant difference between two groups in terms of age, occupation, educational level and marital status except for economic status which was higher in econstruction group. The mean score for BI for BCS was 33.4 and for reconstruction group was 33.8. There was no significant difference between two groups in term of body image, also between demographic variables and body image. The mean score for patient satisfaction was 9.49 in BCS group and 8.89 in reconstruction group (P=0.004). Two groups were significantly different in term of satisfaction, it means that BCS patients were more satisfied about their surgery. Older patients were more satisfied in comparison to younger ones.
Conclusion: Breast Conserving Surgery and Mastectomy with reconstruction by prosthesis were not significantly different in term of Body Image, but the satisfaction of surgery was worse in reconstruction group. The preferred option for breast cancer surgery is breast conservation if there are no contraindications. However reconstruction should be offered to patients for better body image and satisfaction.
Mohadeseh Shayeghan, Romina Mehdizadeh, Flora Forouzesh, Hassan Sanati, , Mohammad Amin Javidi, Alireza Madjid Ansari,
Volume 15, Issue 2 (Iranian Journal of Breast Diseases 2022)
Abstract
Introduction: Breast cancer is the most common cancer and the first cause of cancer-related death in women worldwide. Although admirable achievements have been made in finding new therapeutic interventions, introducing efficient approaches with the least side effect is still undoubtedly demanded. Exposure to extremely-low frequency electromagnetic field (ELF-EMF) with specific parameters of frequency, intensity, and duration seems to show promising results in cancer treatments. In this study we investigated the possible anti-cancer role of ELF-EMF in BT-474 breast cancer cells.
Methods: The BT474 breast cancer cell lines and normal MCF10A cells were exposed to sinusoidal ELF-EMF (100mT, 1Hz) for 2h/d for 5 days. The survival and apoptosis rates of these cells were measured using trypan blue and flow cytometry, respectively. Also, to measure the mRNA expression level of estrogen receptor (ER), progesterone receptor (PR), and ERBB2 (HER2) genes, we used real-time PCR.
Results: ELF-EMF induced apoptosis in about 69% of BT474 (p˂0.05) but not in the MCF10A cells. Also, the gene expression analysis revealed a decrease in ERBB2 and PR expression and an increase in ER expression levels in the experimental group compared with the control group in BT-474 cells.
Conclusion: Exposure to an ELF-EMF of 100 mT, 1 Hz, for 5 days, 2 h/d, can induce significant apoptosis in BT474 cells. Furthermore, it can affect important genes related to breast cancer (decreasing ERBB2 and PR and increasing ER expression), which may be beneficial as possible adjuvant therapy.
Vahid Sari-Sarraf, Javad Vakili, Maryam Heidaryan,
Volume 16, Issue 3 (Iranian Journal of Breast Diseases 2023)
Abstract
Introduction: Obesity is a chronic disease induced by imbalance of energy homeostasis which has been associated with risk of menopausal estrogen-dependent breast cancer. The present study aimed to examine the effect of 12-week concurrent (aerobic-resistance) training on the inflammation marker [Estradiol, Tumor Necrosis Factor-α (TNF-α), Interleukin-6(IL-6)] and physical performance (VO2max, balance, flexibility and strength) in obese postmenopausal women.
Methods: Our research was an unblinded randomized controlled clinical trial. Thirty sedentary and obese postmenopausal women were recruited [age 45–55years, overweight or obese (BMI >25 kg/m2), and inactive (<150 min/week of physical activity) and had an elevated Gail 5-year risk score of breast cancer (>1.66%)] and randomly divided into concurrent training (CT, n=12) and control group (CG, n=13).The participant’s took part in a 12-week supervised intervention training 5 days/week, (each session of which involved 60 minutes of strength training and 30 minutes of aerobic training). Blood samples were taken from the volunteers to measure estradiol and TNF-α and IL-6. Physical function (strength, VO2max, flexibility and balance) were evaluated pre, mid and post-intervention. Quantitative expression was evaluated using 2-∆∆ct method and REST software. ANOVA tests with Bonferroni correction were used to compare the groups at a significance level of α<0.05.
Results: In response to training, total fat mass (FM) , lean body mass(LBM) and waist circulation(WC) in the concurrent training group improved significantly compared with the control group (P < 0.05). The CT group experienced a reduction in FM (-7.73%; P <0.05) and an increase in LBM (2.5%; P <0.05).A significant decrease in the expression of IL-6 (P=0.004) and TNF-α (P=0.0013) was observed in the experimental group compared to the control group. There was no significant difference in estradiol levels in the experimental group compared to the control (P>0.05). VO2max (P=0.001), balance (P=0.001), strength [hand grip (32.7%), leg strength (31.4%)] and flexibility (P=0.002), in the experimental group increased significantly compared to the control group.
Conclusion: The concurrent training and exercise-induced fat mass loss appears to slow the increase of pro inflammatory cytokines in postmenopausal women that is an established risk factor of breast cancer. Thus, this study provides additional evidences to the intricate interaction among estradiol, inflammatory cytokines, adipose tissue and muscle mass in postmenopausal women.
Shahpar Haghighat, Zahra Omidi, Vahid Farajivafa, Maryam Ansari, Aida Bagheri, Akram Sajadian, Shiva Moghadam, Hossein Foudazi, Farid Zayeri,
Volume 17, Issue 4 (Iranian Journal of Breast Diseases 2025)
Abstract
Introduction: The EORTC QLQ-BR45 and QLQ-BR42 questionnaires have been developed to measure the quality of life in breast cancer patients, with 22 and 19 additional items, respectively, compared to the QLQ-BR23 questionnaire. The current project had the objective of evaluating the construct validity of the Persian translation of the QLQ-BR45 and QLQ-BR42 questionnaires.
Methods: After confirming the Persian translation of the EORT QLQ-BR45 questionnaire, 480 samples were enrolled in the study for its psychometric evaluation. Confirmatory factor analysis was used to assess the performance of the item and scale of the QLQ-BR45 and QLQ-BR42 questionnaires' total scores and their subscales. Due to the lack of statistical acceptance of the calculated indices, the construct validity of the 23 and 22 questions of QLQ-BR45 was assessed separately to suggest a more appropriate scoring system for these questionnaires.
Results: In the confirmatory factor analysis of the EORTC QLQ-BR45 tool, the indices RMSEA, NFI, NNFI, and CFI were 0.099, 0.516, 0.638, and 0.676, respectively. The QLQ-BR42 factor analysis showed that the indices were 0.111, 0.742, 0.6, and 0.646, respectively. The factor analysis results for the QLQ-BR23 tool showed NFI, NNFI, CFI, and RMSEA values of 0.830, 0.886, 0.909, and 0.061, respectively. In 22 additional items of the QLQ-BR45, these indexes were 0.853, 0.917, 0.913, and 0.07, respectively, all of which indicate acceptable model fit.
Conclusion: As per the current study, the 45 items in the EORTC QLQ-BR45 tool are not a good fit in the combined factor model. Instead of integrating the two sections mentioned, it is suggested that the new 22-item tool be used as an instrument to assess the quality of life in breast cancer patients.
Milad Pezeshki, Jamshid Ansari, Mahdi Nakhaee, Saeid Ziaei, Omid Moeini, Roja Valipoor, Hasti Beig Verdi,
Volume 18, Issue 1 (Iranian Journal of Breast Diseases 2025)
Abstract
Introduction: The present case-control study was conducted between September 2016 and August 2019 at Ayatollah Khansari Hospital in Arak (Iran) and aimed to comprehensively identify risk factors associated with breast cancer among local women.
Methods: The research included 400 confirmed breast cancer cases and 400 age-matched healthy controls randomly selected from female hospital visitors. Sample size calculation was justified based on prior epidemiological studies assuming a breast cancer prevalence of approximately 50%, with calculations set at a 95% confidence interval and 80% statistical power. Data collection was performed using an interviewer-administered standardized questionnaire covering domains, such as socio-demographic characteristics, reproductive history, medical conditions, lifestyle behaviors, and family history. Data analysis utilized binary and multivariate logistic regression conducted through the SPSS (version 16) software, allowing for rigorous identification of independent risk factors.
Results:The results identified significant breast cancer risk factors, notably including family history of breast cancer (OR=12.02, 95% CI: 4.20–32.56, P<0.001), low education level (OR=6.38, 95% CI: 4.71–11.47, P<0.001), older age at first pregnancy (OR=3.21, 95% CI: 1.83–4.61, P<0.001), and early menarche (OR=2.43, 95% CI: 1.81–4.33, P<0.001). Urban lifestyle was found not to be significantly associated with breast cancer risk in multivariate analysis (OR=1.13, 95% CI: 0.98–1.40, P=0.068).
Conclusion: These findings underscore the necessity for targeted genetic screening and tailored educational programs, particularly addressing women with lower educational status and family history of breast cancer, to improve early detection and prevention.
