Mahsa Akbari Oryani, Fatemeh Alizadeh Mousavi, Anita Alenabi, Mohammad Naser Forghani-Tarighan, Azadeh Jabbari, Maliheh Dadgar-Moghadam,
Volume 17, Issue 3 (Iranian Journal of Breast Diseases 2024)
Abstract
Introduction: Intra-operative frozen section analysis (IOFSA) during breast-conserving surgery (BCS) is recommended to reduce the need for reoperation and its complications. The present study aimed to assess the sensitivity and specificity of IOFSA to determine the margin in specimens of breast cancer lumpectomy during BCS in patients with invasive and in situ breast carcinoma.
Methods: We performed IOFSA during breast-conserving surgery for 151 patients with breast cancer and a positive margin was defined as tumor cells (either invasive or in situ carcinoma) extended to the inked margin or extended to within 2 mm of the inked margin. The results of frozen sections (margin status) were reported to the surgeon. Then tissue was fixed and embedded in paraffin for definitive histological analysis and future comparison.
Results: The obtained results indicated that sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of the frozen section were 96.42%, 94.73%, 91.52%, 97.82%, and 95.36%, respectively.
Conclusion: As evidenced by the results of this study, the use of IOFSA during breast-conserving surgery could lead to a 5-fold reduction in the need for reoperation and risk of reoperation complications, such as anesthesia and cosmetic complications, as well as psychological and financial burdens.
