Faranak Sadeghipoor Vojdani, Hamid Agha-Alinejad, Mahdiyeh Molanouri Shamsi, Sara Soudi, Sana Khanchi,
Volume 12, Issue 3 (11-2019)
Abstract
Introduction: E-cadherin is expressed in most normal epithelial tissues. Loss of E-cadherin can cause dedifferentiation and invasiveness in human carcinomas, leading E-cadherin to be classified as a tumor suppressor. Therefore, the aim of this study was to investigate the effect of interval training on the expression of tumor suppressor gene E-cadherin in breast cancer-bearing BALB/c mice.
Methods: Twenty female BALB/c mice were purchased from the Pasteur Institute and transferred to the Animal Laboratory of Tarbiat Modares University and randomly divided into four groups of training-cancer-rest, training-cancer-training, rest-cancer-rest, and rest-cancer-training. Cancer was induced by subcutaneous injection of 4T1 cell line. The mice performed an average-intensity interval training for 10 weeks, 5 days per week. Forty-eight hours after the last exercise session, the mice were sacrificed to measure the research variables. Gene expression was investigated using real-time PCR. The Kruskal-Wallis test was used to determine the statistical differences between groups.
Results: There was a significant difference in the E-cadherin gene expression between the training-cancer-training and rest-cancer-rest groups (p = 0.03). This difference was also observed between the training-cancer-training and training-cancer-rest groups (p = 0.04).
Conclusion: Interval exercise training may influence the expression of major tumor suppressor genes and systemic inflammation involved in the development of metastasis and even reverse this process.
Fereshteh Ahmadabadi, Marziyeh Saghebjoo, Reyhane Hoshyar,
Volume 13, Issue 2 (7-2020)
Abstract
Introduction: Cachexia is a cancer complication that is associated with increased weight loss. Apoptosis has been known as one of the tissue-wasting pathways that cause weight loss and multiple organ failure in cancer-related cachexia. Various factors, including exercise training, can be effective in the reduction of cancer cachexia. In the present study, the effect of four weeks of high-intensity interval training (HIIT) on some biochemical indices of apoptosis in the liver tissue of breast tumor-bearing mice was investigated.
Methods: In the present experimental study, female BALB/c mice were randomly divided two cancerous groups (control and HIIT) following the induction of breast cancer by the injection of the 4T1 cell line and sham group (phosphate buffer saline injection). Each HIIT session included 6 intervals of 3 minutes and 20 seconds (80%-95% of VO2max) with 1-min active recovery (30%-35% of VO2max), performed for 4 weeks, 5 days per week.
Results: The level of caspase-3 showed a reduction in the HIIT group compared with the control group (P < 0.01). The results also demonstrated an increase in the level of Bcl-2 and Bcl-2 to Bax ratio in the HIIT group compared with the control group (P = 0.01).
Conclusion: Based on the results, it seems that HIIT can reduce liver tissue wasting associated with breast cancer by decreasing caspase-3 and increasing Bcl-2 to Bax ratio.
Amin Isanejad, Behroz Gharib, Ali Gahnbari Motlagh, Somayeh Nazari,
Volume 14, Issue 3 (11-2021)
Abstract
Introduction: Exercise has been proposed as a medicine for the control and treatment of cancer and its complications. The aim of the present study was to compare the effect of 12 weeks of high-intensity interval training and moderate continuous aerobic training on quality of life in women with breast cancer undergoing hormone therapy.
Methods: 39 patients with breast cancer undergoing hormone therapy were randomly assigned to 3 groups: (1) high-intensity interval training (HIIT; n = 13), (2) moderate-intensity continuous training (MICT; n = 14), and (3) control group (n = 12). The intervention groups performed their exercises for 12 weeks, 3 sessions per week. Quality of life was measured using the Functional Assessment of Cancer Therapy-General (FACT-G) before and after the intervention. Data were analyzed using an ANCOVA test.
Results: The physical well-being domain scores significantly improved in the MICT group compared with the control group (P = 0.010). The emotional dimension scores in both groups of HIIT (P = 0.010) and MCIT (P = 0.016) significantly improved compared with the control group. In the functional dimension, a significant difference was observed between the HIIT group and the control group (P = 0.050). Total quality of life scores for both the HIIT group (P = 0.001) and the MICT group (P = 0.005) were significantly increased compared with the control group.
Conclusion: The results of this study show that both interval and continuous exercise programs can improve quality of life in breast cancer patients, although a larger sample is needed to confirm the clinical significance of these initial findings.
