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Volume 13, Issue 1 (Iranian Journal of Breast Disease 2020)
ijbd 2020, 13(1): 55-65 |
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Shiravand F, Nourollahi Z, Valipour Dehnou V. The Effect of 8 Weeks of HICT Training on Serum Levels of BDNF and TNFα and Aerobic Power in Breast Cancer Survivors: Randomized Clinical Trial. ijbd 2020; 13 (1) :55-65
URL: http://ijbd.ir/article-1-771-en.html
URL: http://ijbd.ir/article-1-771-en.html
1- Department of Physical Education and Sport Sciences, Chamran University, Ahwaz, Iran
2- Department of Sport Sciences, Lorestan University, Khorramabad, Iran
3- Department of Sport Sciences, Lorestan University, Khorramabad, Iran ,valipour414@yahoo.com
2- Department of Sport Sciences, Lorestan University, Khorramabad, Iran
3- Department of Sport Sciences, Lorestan University, Khorramabad, Iran ,
Abstract: (4082 Views)
Introduction: In patients with breast cancer, low serum brain-derived neurotrophic factor (BDNF) levels and high serum tumor necrosis factor (TNF)-α level have been reported. Therefore, the present study aimed to investigate the effect of eight weeks of high-intensity circuit training on serum levels of BDNF and TNFα and aerobic power in breast cancer survivors.
Methods: This randomized controlled trial was conducted at Shahid Rahimi Hospital Oncology Center in Khorramabad in 2018. Seventeen breast cancer survivors were selected from a group of 55 women who had undergone chemotherapy and radiation therapy and randomly divided into an exercise (n = 9) or a control (n = 8) group. The exercise group performed high-intensity circuit training (HICT) three sessions per week for eight weeks. Data were analyzed using a paired-samples t test and an analysis of covariance.
Results: The results of the t test showed that after eight weeks, serum levels of BDNF and TNF-α were significantly increased in both groups (p ˂ 0.05), although the difference between the groups was not significant. Aerobic power significantly increased only in the exercise group (p = 0.0005). In addition, the results of the analysis of covariance showed only a significant difference in aerobic power between the two groups (p ˂ 0.05).
Conclusion: Eight weeks of HICT training in breast cancer survivors can increase aerobic capacity without affecting serum levels of BDNF and TNFα.
Methods: This randomized controlled trial was conducted at Shahid Rahimi Hospital Oncology Center in Khorramabad in 2018. Seventeen breast cancer survivors were selected from a group of 55 women who had undergone chemotherapy and radiation therapy and randomly divided into an exercise (n = 9) or a control (n = 8) group. The exercise group performed high-intensity circuit training (HICT) three sessions per week for eight weeks. Data were analyzed using a paired-samples t test and an analysis of covariance.
Results: The results of the t test showed that after eight weeks, serum levels of BDNF and TNF-α were significantly increased in both groups (p ˂ 0.05), although the difference between the groups was not significant. Aerobic power significantly increased only in the exercise group (p = 0.0005). In addition, the results of the analysis of covariance showed only a significant difference in aerobic power between the two groups (p ˂ 0.05).
Conclusion: Eight weeks of HICT training in breast cancer survivors can increase aerobic capacity without affecting serum levels of BDNF and TNFα.
Type of Study: Applicable |
Received: 2019/08/27 | Accepted: 2019/12/23 | Published: 2020/05/21
Received: 2019/08/27 | Accepted: 2019/12/23 | Published: 2020/05/21
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