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Volume 16, Issue 4 (Iranian Journal of Breast Diseases 2024)
ijbd 2024, 16(4): 4-20 |
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Research code: CMRC-0035
Ethics code: IR.AJUMS.REC.1400.383
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Roshanazadeh M, rashidi M, sanaei A, azizi dariuni H, emami razavi A, Adelipour M. TRIM14 and TRIM29 as potential tumor markers for breast cancer diagnosis. ijbd 2024; 16 (4) :4-20
URL: http://ijbd.ir/article-1-1036-en.html
URL: http://ijbd.ir/article-1-1036-en.html
Mohammadreza Roshanazadeh1 
, Mojtaba Rashidi1 , Arash Sanaei1 , Hossein Azizi dariuni1 , Amirnader Emami razavi2 , Maryam Adelipour * 3
, Mojtaba Rashidi1 , Arash Sanaei1 , Hossein Azizi dariuni1 , Amirnader Emami razavi2 , Maryam Adelipour * 3
1- Cellular and Molecular Research Center, Medical Basic Sciences Research Institution, Department of Clinical Biochemistry, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2- Iran National Tumor Bank, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran
3- Cellular and Molecular Research Center, Medical Basic Sciences Research Institution, Department of Clinical Biochemistry, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran ,adelipour-m@ajums.ac.ir
2- Iran National Tumor Bank, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran
3- Cellular and Molecular Research Center, Medical Basic Sciences Research Institution, Department of Clinical Biochemistry, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran ,
Abstract: (775 Views)
Introduction: Various members of the Tripartite-motif protein family contribute to different types of cancer, although the role of these factors in breast cancer is unclear. TRIM14 and TRIM29 have been reported to be overexpressed and play oncogenic roles in specific cancers.
Methods: A total of 40 pairs of tumor tissues and adjacent normal tissues of breast cancer patients were obtained. Relative gene expression of TRIM14 and TRIM29 were determined through quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) using specific primers.
Results: TRIM14 and TRIM29 were both overexpressed in breast tumor samples. The expression of TRIM14 was associated with tumor size, stage, and invasiveness. Nonetheless, no association was found between TRIM14 and the grade of the tumor. Also, TRIM29 gene expression was positively correlated with tumor size, stage, grade, and invasiveness. No correlation was found between the expression of TRIM14 and TRIM29.
Conclusion: Based on our results, we propose TRIM14 and TRIM29 as potential tumor markers in breast cancer.
Methods: A total of 40 pairs of tumor tissues and adjacent normal tissues of breast cancer patients were obtained. Relative gene expression of TRIM14 and TRIM29 were determined through quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) using specific primers.
Results: TRIM14 and TRIM29 were both overexpressed in breast tumor samples. The expression of TRIM14 was associated with tumor size, stage, and invasiveness. Nonetheless, no association was found between TRIM14 and the grade of the tumor. Also, TRIM29 gene expression was positively correlated with tumor size, stage, grade, and invasiveness. No correlation was found between the expression of TRIM14 and TRIM29.
Conclusion: Based on our results, we propose TRIM14 and TRIM29 as potential tumor markers in breast cancer.
Type of Study: Research |
Subject:
molecular cell
Received: 2023/01/28 | Accepted: 2023/11/26 | Published: 2024/01/7
Received: 2023/01/28 | Accepted: 2023/11/26 | Published: 2024/01/7
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