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Volume 17, Issue 4 (Iranian Journal of Breast Diseases 2025)
ijbd 2025, 17(4): 83-95 |
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Research code: 400000163
Ethics code: IR.KMU.AH.REC.1400.133
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Abolhassanizadeh F, Kouhestani Parizi M, Abbasi F, Abbasi L. Comparison of Blood Lipid Profiles and Body Mass Index between Women with Breast Cancer and Healthy Controls: A Case-Control Study. ijbd 2025; 17 (4) :83-95
URL: http://ijbd.ir/article-1-1119-en.html
URL: http://ijbd.ir/article-1-1119-en.html
1- Department of Surgery, Afzalipoor Hospital, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
2- Department of Surgery, Afzalipoor Hospital, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran ,Fatemeabbasi100@gmail.com
3- Physical Therapy Department, School of Rehabilitation Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
2- Department of Surgery, Afzalipoor Hospital, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran ,
3- Physical Therapy Department, School of Rehabilitation Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
Abstract: (357 Views)
Introduction: Breast cancer is the most prevalent cancer among women in Iran, affecting approximately 7,000 individuals annually. The present study aims to investigate the associations between blood lipid profiles, body mass index (BMI), and the risk of breast cancer.
Materials & Methods: This case-control study involved 55 women diagnosed with breast cancer and 65 healthy controls, all recruited from Kerman, Iran. Blood lipid levels, including cholesterol, triglycerides, high-density lipoprotein (HDL), and low-density lipoprotein (LDL), were measured, and BMI was calculated. Additionally, data on menopausal status, lymph node involvement, and chemotherapy history were collected for all participants.
Results: The breast cancer group demonstrated significantly higher levels of cholesterol, triglycerides, and HDL compared to the control group (P<0.05). The mean BMI in the breast cancer group was 2.81, compared to 2.38 in the control group. Furthermore, 61.8% of the breast cancer patients were classified as overweight or obese, and a higher proportion of postmenopausal women were observed in the case group (27.3%) compared to the control group (3.1%).
Conclusion: Elevated levels of blood lipids and BMI may be associated with an increased risk of breast cancer, highlighting the importance of managing both weight and lipid levels. Region-specific research is crucial to account for the influence of cultural and dietary factors on these associations.
Materials & Methods: This case-control study involved 55 women diagnosed with breast cancer and 65 healthy controls, all recruited from Kerman, Iran. Blood lipid levels, including cholesterol, triglycerides, high-density lipoprotein (HDL), and low-density lipoprotein (LDL), were measured, and BMI was calculated. Additionally, data on menopausal status, lymph node involvement, and chemotherapy history were collected for all participants.
Results: The breast cancer group demonstrated significantly higher levels of cholesterol, triglycerides, and HDL compared to the control group (P<0.05). The mean BMI in the breast cancer group was 2.81, compared to 2.38 in the control group. Furthermore, 61.8% of the breast cancer patients were classified as overweight or obese, and a higher proportion of postmenopausal women were observed in the case group (27.3%) compared to the control group (3.1%).
Conclusion: Elevated levels of blood lipids and BMI may be associated with an increased risk of breast cancer, highlighting the importance of managing both weight and lipid levels. Region-specific research is crucial to account for the influence of cultural and dietary factors on these associations.
Type of Study: Research |
Subject:
Diagnosis, treatment, rehabilitation
Received: 2024/07/3 | Accepted: 2024/11/6 | Published: 2024/12/27
Received: 2024/07/3 | Accepted: 2024/11/6 | Published: 2024/12/27
References
1. Ferlay J, Ervik M, Lam F, Colombet M, Mery L, Piñeros M, et al. Global cancer observatory: cancer today. Lyon: International agency for research on cancer. 2020;20182020.
2. Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2022. CA: a cancer journal for clinicians. 2022;72(1). [DOI:10.3322/caac.21708] [PMID]
3. Macdonald S, Oncology R, General M. Breast Cancer Facts & Figures 2022-2024. Am Cancer Soc. 2022;10:201006001.
4. Anderson LN, Cotterchio M, Vieth R, Knight JA. Vitamin D and calcium intakes and breast cancer risk in pre-and postmenopausal women. The American journal of clinical nutrition. 2010;91(6):1699-707. [DOI:10.3945/ajcn.2009.28869] [PMID]
5. Brennan SF, Cantwell MM, Cardwell CR, Velentzis LS, Woodside JV. Dietary patterns and breast cancer risk: a systematic review and meta-analysis. The American journal of clinical nutrition. 2010;91(5):1294-302. [DOI:10.3945/ajcn.2009.28796] [PMID]
6. Shikany JM, Redden DT, Neuhouser ML, Chlebowski RT, Rohan TE, Simon MS, et al. Dietary glycemic load, glycemic index, and carbohydrate and risk of breast cancer in the Women's Health Initiative. Nutrition and cancer. 2011;63(6):899-907. [DOI:10.1080/01635581.2011.587227] [PMID] []
7. Neilson HK, Farris MS, Stone CR, Vaska MM, Brenner DR, Friedenreich CM. Moderate-vigorous recreational physical activity and breast cancer risk, stratified by menopause status: a systematic review and meta-analysis. Menopause. 2017;24(3):322-44. [DOI:10.1097/GME.0000000000000745] [PMID]
8. Friedenreich CM, Neilson HK, Lynch BM. State of the epidemiological evidence on physical activity and cancer prevention. European journal of cancer. 2010;46(14):2593-604. [DOI:10.1016/j.ejca.2010.07.028] [PMID]
9. Green J, Cairns BJ, Casabonne D, Wright FL, Reeves G, Beral V, et al. Height and cancer incidence in the Million Women Study: prospective cohort, and meta-analysis of prospective studies of height and total cancer risk. The lancet oncology. 2011;12(8):785-94. [DOI:10.1016/S1470-2045(11)70154-1] [PMID]
10. McTiernan A, Ulrich C, Slate S, Potter J. Physical activity and cancer etiology: associations and mechanisms. Cancer Causes & Control. 1998;9(5):487-509. [DOI:10.1023/A:1008853601471] [PMID]
11. Coughlin SS, Smith SA. The insulin-like growth factor axis, adipokines, physical activity, and obesity in relation to breast cancer incidence and recurrence. Cancer and clinical oncology. 2015;4(2):24. [DOI:10.5539/cco.v4n2p24] [PMID] []
12. Berrino F, Villarini A, Traina A, Bonanni B, Panico S, Mano MP, et al. Metabolic syndrome and breast cancer prognosis. Breast cancer research and treatment. 2014;147(1):159-65. [DOI:10.1007/s10549-014-3076-6] [PMID]
13. Welti LM, Beavers DP, Caan BJ, Sangi-Haghpeykar H, Vitolins MZ, Beavers KM. Weight fluctuation and cancer risk in postmenopausal women: the women's health initiative. Cancer Epidemiology and Prevention Biomarkers. 2017;26(5):779-86. [DOI:10.1158/1055-9965.EPI-16-0611] [PMID] []
14. His M, Dartois L, Fagherazzi G, Boutten A, Dupré T, Mesrine S, et al. Associations between serum lipids and breast cancer incidence and survival in the E3N prospective cohort study. Cancer Causes & Control. 2017;28(1):77-88. [DOI:10.1007/s10552-016-0832-4] [PMID]
15. Touvier M, Fassier P, His M, Norat T, Chan DS, Blacher J, et al. Cholesterol and breast cancer risk: a systematic review and meta-analysis of prospective studies. British Journal of Nutrition. 2015;114(3):347-57.Cedó L, Reddy ST, Mato E, Blanco-Vaca F, Escolà-Gil JC. HDL and LDL: Potential New Players in Breast Cancer Development. J Clin Med. 2019;8(6). [DOI:10.3390/jcm8060853] [PMID] []
16. Lu C-W, Lo Y-H, Chen C-H, Lin C-Y, Tsai C-H, Chen P-J, et al. VLDL and LDL, but not HDL, promote breast cancer cell proliferation, metastasis and angiogenesis. Cancer letters. 2017;388:130-8. [DOI:10.1016/j.canlet.2016.11.033] [PMID]
17. Baer HJ, Tworoger SS, Hankinson SE, Willett WC. Body fatness at young ages and risk of breast cancer throughout life. American journal of epidemiology. 2010;171(11):1183-94. [DOI:10.1093/aje/kwq045] [PMID] []
18. Narii N, Zha L, Komatsu M, Kitamura T, Sobue T, Ogawa T. Cholesterol and breast cancer risk: a cohort study using health insurance claims and health checkup databases. Breast Cancer Research and Treatment. 2023;199(2):315-22. [DOI:10.1007/s10549-023-06917-z] [PMID] []
19. Mahdavifar N, Pakzad R, Ghoncheh M, Pakzad I, Moudi A, Salehiniya H. Spatial analysis of breast cancer incidence in Iran. Asian Pacific Journal of Cancer Prevention. 2016;17(S3):59-64. [DOI:10.7314/APJCP.2016.17.S3.59] [PMID]
20. Martínez-Rodríguez OP, Thompson-Bonilla MdR, Jaramillo-Flores ME. Association between obesity and breast cancer: molecular bases and the effect of flavonoids in signaling pathways. Critical Reviews in Food Science and Nutrition. 2020;60(22):3770-92. [DOI:10.1080/10408398.2019.1708262] [PMID]
21. Pelton K, Coticchia CM, Curatolo AS, Schaffner CP, Zurakowski D, Solomon KR, et al. Hypercholesterolemia induces angiogenesis and accelerates growth of breast tumors in vivo. The American journal of pathology. 2014;184(7):2099-110. [DOI:10.1016/j.ajpath.2014.03.006] [PMID] []
22. Garcia-Estevez L, Moreno-Bueno G. Updating the role of obesity and cholesterol in breast cancer. Breast Cancer Research. 2019;21(1):35. [DOI:10.1186/s13058-019-1124-1] [PMID] []
23. Raza U, Asif MR, Rehman AB, Sheikh A. Hyperlipidemia and hyper glycaemia in Breast Cancer Patients is related to disease stage. Pak J Med Sci. 2018;34(1):209-14. [DOI:10.12669/pjms.341.14841] [PMID] []
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