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Volume 18, Issue 4 (Iranian Journal of Breast Diseases 2026)
ijbd 2026, 18(4): 88-101 |
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Budiono M B, Anita K W, Solimun S, Saputra A. Association of Mutant p53 Expression with Lymph Node Metastasis and Histological Grading in Breast Cancer Patients. ijbd 2026; 18 (4) :88-101
URL: http://ijbd.ir/article-1-1209-en.html
URL: http://ijbd.ir/article-1-1209-en.html
1- Department of Oncology Surgery, Dr. Saiful Anwar General Hospital – Brawijaya University, Malang, Indonesia
2- Department of Pathological Anatomy, Brawijaya University, Malang, Indonesia
3- Department of Statistics, Faculty of Mathematics and Natural Science, Brawijaya University, Malang, Indonesia
4- Department of Surgery, Brawijaya University – Dr. Saiful Anwar General Hospital, Malang, Indonesia ,apriandasaputra@gmail.com
2- Department of Pathological Anatomy, Brawijaya University, Malang, Indonesia
3- Department of Statistics, Faculty of Mathematics and Natural Science, Brawijaya University, Malang, Indonesia
4- Department of Surgery, Brawijaya University – Dr. Saiful Anwar General Hospital, Malang, Indonesia ,
Abstract: (17 Views)
Introduction: Breast cancer remains the most prevalent malignancy among women worldwide, with lymph node metastasis serving as a critical determinant of prognosis. Mutations in the TP53 gene, leading to the expression of dysfunctional p53 protein, have been implicated in tumor progression and nodal dissemination. This study aimed to analyze the association between mutant P53 expression and lymph node metastasis (LNM) as well as histopathological grading in breast cancer patients.
Methods: Retrospective cross-sectional study of 83 patients treated (Jan 2021–Dec 2024) at Dr. Saiful Anwar General Hospital, Indonesia. Mutant p53 was assessed by immunohistochemistry. Associations with LNM were tested by chi-square; correlations with grade by Spearman’s rho.
Results: The mean age of the subjects was 51.27 ± 10.24 years. Based on nodal staging, the majority of patients were classified as N1 (67.47%). Histopathological grading revealed Grade 3 as the most prevalent (53.0%). Statistical analysis demonstrated a significant association between mutant P53 expression and lymph node metastasis (p < 0.001; r = 0.670), indicating a strong positive correlation. In contrast, no significant association was observed between mutant P53 expression and histopathological grading (p = 0.485; r = 0.078).
Conclusion: Mutant p53 expression is strongly associated with lymph node metastasis but not with histological grade in breast cancer. Prospective studies incorporating advanced assessment methods are warranted to validate these findings.
Methods: Retrospective cross-sectional study of 83 patients treated (Jan 2021–Dec 2024) at Dr. Saiful Anwar General Hospital, Indonesia. Mutant p53 was assessed by immunohistochemistry. Associations with LNM were tested by chi-square; correlations with grade by Spearman’s rho.
Results: The mean age of the subjects was 51.27 ± 10.24 years. Based on nodal staging, the majority of patients were classified as N1 (67.47%). Histopathological grading revealed Grade 3 as the most prevalent (53.0%). Statistical analysis demonstrated a significant association between mutant P53 expression and lymph node metastasis (p < 0.001; r = 0.670), indicating a strong positive correlation. In contrast, no significant association was observed between mutant P53 expression and histopathological grading (p = 0.485; r = 0.078).
Conclusion: Mutant p53 expression is strongly associated with lymph node metastasis but not with histological grade in breast cancer. Prospective studies incorporating advanced assessment methods are warranted to validate these findings.
Type of Study: Research |
Subject:
molecular cell
Received: 2025/09/28 | Accepted: 2025/12/23 | Published: 2026/01/25
Received: 2025/09/28 | Accepted: 2025/12/23 | Published: 2026/01/25
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