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Volume 10, Issue 2 (Iranian Quarterly Journal of Breast Diseases 2017)
ijbd 2017, 10(2): 7-15 |
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Olfatbakhsh A, Haghighat S, Khani M, Beheshtian T, Alavi N, Sari F et al . Evaluation of Ultrasound Accuracy in Axillary Lymph node Involvement in Breast Cancer Patients. ijbd 2017; 10 (2) :7-15
URL: http://ijbd.ir/article-1-625-en.html
URL: http://ijbd.ir/article-1-625-en.html
Asiie Olfatbakhsh *1 
, Shahpar Haghighat2 , Mansoureh Khani3 , Toktam Beheshtian4 , Nasrin Alavi4 , Fatemeh Sari4 , Parisa Hosseinpour3
, Shahpar Haghighat2 , Mansoureh Khani3 , Toktam Beheshtian4 , Nasrin Alavi4 , Fatemeh Sari4 , Parisa Hosseinpour3
1- Breast Disease Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR , folfatbakhsh@yahoo.com
2- Quality of life Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR
3- Breast Cancer Research Center, Motamed Cancer Institute, ACECR
4- Breast Disease Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR
2- Quality of life Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR
3- Breast Cancer Research Center, Motamed Cancer Institute, ACECR
4- Breast Disease Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR
Abstract: (19289 Views)
Introduction: The status of the axillary lymph node is the most important factor in determining the prognosis of breast cancer. The aim of this study was to evaluate the sensitivity and specificity of Axillary Ultrasound (AUS) in the diagnosis of lymph node involvement in breast cancer patients referred to the Breast Cancer Research Center (BCRC) between March 2015 and Aug 2016.
Methods: Through a cross sectional study, all patients with a diagnosis of non-metastatic breast cancer with Stage I, II, IIIA and no chemotherapy before surgery were evaluated. The results of AUS and pathology after surgery were collected and analyzed using SPSS based on sensitivity and specificity formula.
Results: Of a total of 140 patients, the average age was 48.87 and the mean size of masses was 2.31 cm (0.4 -10 cm). Physical examination was positive in %14.6 of patients, positive AUS in %28.6 and pathologic axillary involvement in %39.2 of the patients. Sensitivity, specificity, PPV and NPV of AUS in diagnosing lymph node involvement were %55.5, %88.3, %75 and %76 respectively. Sensitivity, specificity, PPV and NPV of clinical examination were %31.48, %97.67, %89.4 and 69.4. The combination of positive AUS and physical examination were along with pathologic axillary involvement in %92.3 of patients. False positivity and false negativity of AUS were %11.6 and %17.1 in all.
Conclusions: The sensitivity and specificity of AUS in our patients is the same as the results of other countries. Clinical examination alone has a high false negative and low sensitivity, however AUS in addition to physical examination has higher sensitivity which could predict axillary involvement and lead to axillary dissection without sentinel node biopsy. Negative AUS has about %24 false negativity and SLNB could not be omitted until the results of trials would be published.
Methods: Through a cross sectional study, all patients with a diagnosis of non-metastatic breast cancer with Stage I, II, IIIA and no chemotherapy before surgery were evaluated. The results of AUS and pathology after surgery were collected and analyzed using SPSS based on sensitivity and specificity formula.
Results: Of a total of 140 patients, the average age was 48.87 and the mean size of masses was 2.31 cm (0.4 -10 cm). Physical examination was positive in %14.6 of patients, positive AUS in %28.6 and pathologic axillary involvement in %39.2 of the patients. Sensitivity, specificity, PPV and NPV of AUS in diagnosing lymph node involvement were %55.5, %88.3, %75 and %76 respectively. Sensitivity, specificity, PPV and NPV of clinical examination were %31.48, %97.67, %89.4 and 69.4. The combination of positive AUS and physical examination were along with pathologic axillary involvement in %92.3 of patients. False positivity and false negativity of AUS were %11.6 and %17.1 in all.
Conclusions: The sensitivity and specificity of AUS in our patients is the same as the results of other countries. Clinical examination alone has a high false negative and low sensitivity, however AUS in addition to physical examination has higher sensitivity which could predict axillary involvement and lead to axillary dissection without sentinel node biopsy. Negative AUS has about %24 false negativity and SLNB could not be omitted until the results of trials would be published.
Keywords: Breast Cancer, Axillary Ultrasound, Sensitivity, Specificity, Positive Predictive Value, Negative Predictive Value
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Conclusions: The sensitivity and specificity of AUS in our patients is the same as the results of other countries. Clinical examination alone has a high false negative and low sensitivity, however AUS in addition to physical examination has higher sensitivity which could predict axillary involvement and lead to axillary dissection without sentinel node biopsy. Negative AUS has about %24 false negativity and SLNB could not be omitted until the results of trials would be published.
Type of Study: Research |
Subject:
Breast Diseases
Received: 2017/09/27 | Accepted: 2017/09/27 | Published: 2017/09/27
Received: 2017/09/27 | Accepted: 2017/09/27 | Published: 2017/09/27
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