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Volume 13, Issue 2 (Iranian Journal of Breast Disease 2020)
ijbd 2020, 13(2): 59-68 |
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The Effect of Endurance Training Along with Curcumin on VEGF-A Level and VEGFR Gene Expression in Cancer Tissue of Female Mice with Breast Cancer. ijbd 2020; 13 (2) :59-68
URL: http://ijbd.ir/article-1-792-en.html
URL: http://ijbd.ir/article-1-792-en.html
Abstract: (3105 Views)
Introduction: Breast cancer is the most common cancer and leading cause of death among women worldwide. The aim of the present study was to determine synergistic effects of 5 weeks of endurance training along with curcumin on cancer progression, levels of VEGF-A, and gene expression of VEGFR in cancer tissue of female Mice with breast cancer.
Methods: The present study was an experimental study. Forty female BALB/c mice were transplanted with 4T1 tumors and randomly divided into four groups including an endurance training group (E) (5 weeks, five days a week), a curcumin group (CC), an endurance training along with curcumin (E-C), and a control group (C). All animals were killed 24 hours following the last training session, and tumors were immediately extracted. Levels of VEGF-A and gene expression of VEGFR were determined by a western blot and quantitative real-time PCR, respectively. Data were analyzed with a one-way analysis of variance. The level of significance was set at 0.05.
Results: The results of the present study showed a significant decrease in cancer progression (p < 0.001), tumor levels of VEGFA (p < 0.001), and VEGFR expression (p < 0.001) in the E, CC, and—especially—E-C groups compared with the control group.
Conclusion: It seems that 5 weeks of endurance training in combination with curcumin supplementation may have greater inhibitory effect on angiogenesis mechanisms, including VEGF-A/VEFR axis, resulting in greater decrease in cancer progression in mice with breast cancer in comparison with E and CC groups.
Methods: The present study was an experimental study. Forty female BALB/c mice were transplanted with 4T1 tumors and randomly divided into four groups including an endurance training group (E) (5 weeks, five days a week), a curcumin group (CC), an endurance training along with curcumin (E-C), and a control group (C). All animals were killed 24 hours following the last training session, and tumors were immediately extracted. Levels of VEGF-A and gene expression of VEGFR were determined by a western blot and quantitative real-time PCR, respectively. Data were analyzed with a one-way analysis of variance. The level of significance was set at 0.05.
Results: The results of the present study showed a significant decrease in cancer progression (p < 0.001), tumor levels of VEGFA (p < 0.001), and VEGFR expression (p < 0.001) in the E, CC, and—especially—E-C groups compared with the control group.
Conclusion: It seems that 5 weeks of endurance training in combination with curcumin supplementation may have greater inhibitory effect on angiogenesis mechanisms, including VEGF-A/VEFR axis, resulting in greater decrease in cancer progression in mice with breast cancer in comparison with E and CC groups.
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Conclusion: It seems that 5 weeks of endurance training in combination with curcumin supplementation may have greater inhibitory effect on angiogenesis mechanisms, including VEGF-A/VEFR axis, resulting in greater decrease in cancer progression in mice with breast cancer in comparison with E and CC groups.
Type of Study: Research |
Received: 2020/01/1 | Accepted: 2020/02/12 | Published: 2020/08/19
Received: 2020/01/1 | Accepted: 2020/02/12 | Published: 2020/08/19
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