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Volume 15, Issue 1 (Iranian Journal of Breast Diseases 2022)
ijbd 2022, 15(1): 87-102 |
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Ahmadinasab M, Malihialzackerini S, Mohaghegh F, Sodagar S, Sabet M. THE effectiveness of meaning-based existential therapy on anxiety and serum levels of tumor necrosis factor TNFα in women with breast cancer. ijbd 2022; 15 (1) :87-102
URL: http://ijbd.ir/article-1-903-en.html
URL: http://ijbd.ir/article-1-903-en.html
Maryam Ahmadinasab1 
, Saied Malihialzackerini *2 , Fathollah Mohaghegh3 , Sheida Sodagar4 , Mehrdad Sabet5
, Saied Malihialzackerini *2 , Fathollah Mohaghegh3 , Sheida Sodagar4 , Mehrdad Sabet5
1- PhD Student in Health Psychology, Department of Health Psychology, Karaj Branch, Islamic Azad University, Karaj, Iran
2- Department of Health Psychology, Karaj Branch, Islamic Azad University, Karaj, Iran ,zuckerini99@yahoo.com
3- Department of Radiation Oncology, University of Medical Sciences, Arak, Iran
4- Department of Health Psychology, Karaj Branch, Islamic Azad University, Karaj, Iran
5- Department of Psychology, Roodehen Branch, Islamic Azad University, Roodehen, Iran
2- Department of Health Psychology, Karaj Branch, Islamic Azad University, Karaj, Iran ,
3- Department of Radiation Oncology, University of Medical Sciences, Arak, Iran
4- Department of Health Psychology, Karaj Branch, Islamic Azad University, Karaj, Iran
5- Department of Psychology, Roodehen Branch, Islamic Azad University, Roodehen, Iran
Abstract: (2499 Views)
Introduction: Diagnosing cancer can be a very anxious experience, and anxiety can disrupt immune system function. Tumor necrosis factor-alpha (TNFα) is an inflammatory cytokine that is associated with amplified tumor cell proliferation, higher malignancy, increased metastasis, and poor general prognosis for the patients who suffer from breast cancer.
Methods: This study is a randomized clinical trial with follow-up and control group. The experimental group underwent meaning-based existential intervention. Both groups were assessed by Beck Anxiety Questionnaire and serum levels of tumor necrosis factor before, after and three months after the intervention, and data were analyzed by repeated measures analysis of variance.
Results: The experimental group showed a decrease in anxiety scores and serum TNFα levels after receiving a psychotherapy program/interventions compared to the control group. The results show that the mean of TNFα was 47.10± 1.22 and the mean of anxiety was 21.75± 9.30 in the experimental group, while the mean of TNFα was 50.75± 1.71 and the mean of anxiety was 44.7± 12.27 in the control group, this reduction has also been observed in the follow-up phase (0.001≥ p).
Conclusion: Based on the findings, meaning-based existential psychotherapy can reduce anxiety and serum TNFα levels by reducing patients' anxiety and helping to give meaning to life again. Accordingly, this treatment can be used along with medical treatments.
Methods: This study is a randomized clinical trial with follow-up and control group. The experimental group underwent meaning-based existential intervention. Both groups were assessed by Beck Anxiety Questionnaire and serum levels of tumor necrosis factor before, after and three months after the intervention, and data were analyzed by repeated measures analysis of variance.
Results: The experimental group showed a decrease in anxiety scores and serum TNFα levels after receiving a psychotherapy program/interventions compared to the control group. The results show that the mean of TNFα was 47.10± 1.22 and the mean of anxiety was 21.75± 9.30 in the experimental group, while the mean of TNFα was 50.75± 1.71 and the mean of anxiety was 44.7± 12.27 in the control group, this reduction has also been observed in the follow-up phase (0.001≥ p).
Conclusion: Based on the findings, meaning-based existential psychotherapy can reduce anxiety and serum TNFα levels by reducing patients' anxiety and helping to give meaning to life again. Accordingly, this treatment can be used along with medical treatments.
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Conclusion: Based on the findings, meaning-based existential psychotherapy can reduce anxiety and serum TNFα levels by reducing patients' anxiety and helping to give meaning to life again. Accordingly, this treatment can be used along with medical treatments.
Type of Study: Research |
Received: 2021/07/31 | Accepted: 2022/01/2 | Published: 2022/04/30
Received: 2021/07/31 | Accepted: 2022/01/2 | Published: 2022/04/30
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