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:: Volume 11, Issue 1 (Iranian Quarterly Journal of Breast Disease 2018) ::
ijbd 2018, 11(1): 7-16 Back to browse issues page
Changes in Monocyte Populations Following Acute Aerobic Exercise in Breast Cancer Survivors
Nasim Khosravi, Erik Hanson, Vahid Farajivafa, Hamid Agha-Alinejad , Shahpar Haghighat, Mahdieh Molanouri Shamsi, Wiliam Evans, Jordan Lee, Eli Danson, Chad Wagoner, Elizabeth Harell, Kristen Nyrop, Hy Muss, David Bartlett, Cludio Battaglini
Physical Education & Sport Sciences Department, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran , haghaalinejad@mail.modares.ac.ir
Abstract:   (1465 Views)
Introduction: Exercise is now strongly recommended for breast cancer patients to improve their overall health and quality of life. Monocytes play an important role in the cancer immune system and a better understanding of how acute exercise alters the monocyte subsets would aid in exercise prescription.
Methods: Ten breast cancer survivors (age: 59 ± 7.1) who completed their primary cancer treatment within the previous year were evaluated in this study. Using flow cytometry, monocyte subset percentages were evaluated before, immediately after, and 1 hour after 45 minutes of acute, intermittent exercise. Exercise intensity was 60% of peak wattage obtained from a cardiopulmonary exercise test.
Results: The percentage of CD14+ monocytes and CD14+CD16- monocyte subsets changed significantly across the trial (p= 0.016 and p = 0.016, respectively), with a small, non-significant increase immediately after exercise (CD14+: 9%, p= 0.314; CD14+CD16-: 5%, p= 0.594) followed by a larger significant decrease 1 hour after exercise relative to baseline (CD14+: -26%, p= 0.015; CD14+CD16-: -28%, p= 0.021). CD14+CD16+ subpopulation showed a tendency to change across the trial but this did not quite reach significance (p= 0.097).
Conclusion: These findings suggest that acute intermittent exercise mobilizes CD14+ monocytes and CD14+CD16- monocyte subsets in breast cancer survivors in a manner that is comparable to previous reports in healthy individuals. Further studies are warranted to determine the functionality of the mobilized monocytes and the effects of exercise training.
Keywords: Exercise, Breast Cancer, Monocyte, Immune System.
Full-Text [PDF 172 kb]   (643 Downloads)    
Type of Study: Research | Subject: Breast
Received: 2018/02/26 | Accepted: 2018/06/26 | Published: 2018/06/26
These findings suggest that acute intermittent exercise mobilizes CD14+ monocytes and CD14+CD16- monocyte subsets in breast cancer survivors in a manner that is comparable to previous reports in healthy individuals. Further studies are warranted to determine the functionality of the mobilized monocytes and the effects of exercise training
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Khosravi N, Hanson E, Farajivafa V, Agha-Alinejad H, Haghighat S, Molanouri Shamsi M, et al . Changes in Monocyte Populations Following Acute Aerobic Exercise in Breast Cancer Survivors. ijbd. 2018; 11 (1) :7-16
URL: http://ijbd.ir/article-1-659-en.html


Volume 11, Issue 1 (Iranian Quarterly Journal of Breast Disease 2018) Back to browse issues page
فصلنامه علمی- پژوهشی بیماری های پستان ایران Iranian Quarterly Journal of Breast Disease

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