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Volume 11, Issue 1 (Iranian Quarterly Journal of Breast Disease 2018)
ijbd 2018, 11(1): 7-16 |
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Khosravi N, Hanson E, Farajivafa V, Agha-Alinejad H, Haghighat S, Molanouri Shamsi M, et al . Changes in Monocyte Populations Following Acute Aerobic Exercise in Breast Cancer Survivors. ijbd 2018; 11 (1) :7-16
URL: http://ijbd.ir/article-1-659-en.html
URL: http://ijbd.ir/article-1-659-en.html
Nasim Khosravi1 
, Erik Hanson2 , Vahid Farajivafa1 , Hamid Agha-Alinejad * 3, Shahpar Haghighat4 , Mahdieh Molanouri Shamsi5 , Wiliam Evans2 , Jordan Lee2 , Eli Danson2 , Chad Wagoner2 , Elizabeth Harell2 , Kristen Nyrop6 , Hy Muss6 , David Bartlett7 , Cludio Battaglini2
, Erik Hanson2 , Vahid Farajivafa1 , Hamid Agha-Alinejad * 3, Shahpar Haghighat4 , Mahdieh Molanouri Shamsi5 , Wiliam Evans2 , Jordan Lee2 , Eli Danson2 , Chad Wagoner2 , Elizabeth Harell2 , Kristen Nyrop6 , Hy Muss6 , David Bartlett7 , Cludio Battaglini2
1- Physical Education & Sport Sciences Department, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran & Department of Exercise & Sport Science, Exercise Oncology Research Laboratory, University of North Carolina, Chapel Hill, NC USA
2- Department of Exercise & Sport Science, Exercise Oncology Research Laboratory, University of North Carolina, Chapel Hill, NC USA
3- Physical Education & Sport Sciences Department, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran ,haghaalinejad@mail.modares.ac.ir
4- Quality of Life Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
5- Physical Education & Sport Sciences Department, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran
6- Department of Hematology Oncology University of North Carolina, Chapel Hill, NC USA
7- Department of Medicine, Duke University, Durham NC, USA
2- Department of Exercise & Sport Science, Exercise Oncology Research Laboratory, University of North Carolina, Chapel Hill, NC USA
3- Physical Education & Sport Sciences Department, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran ,
4- Quality of Life Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
5- Physical Education & Sport Sciences Department, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran
6- Department of Hematology Oncology University of North Carolina, Chapel Hill, NC USA
7- Department of Medicine, Duke University, Durham NC, USA
Abstract: (5835 Views)
Introduction: Exercise is now strongly recommended for breast cancer patients to improve their overall health and quality of life. Monocytes play an important role in the cancer immune system and a better understanding of how acute exercise alters the monocyte subsets would aid in exercise prescription.
Methods: Ten breast cancer survivors (age: 59 ± 7.1) who completed their primary cancer treatment within the previous year were evaluated in this study. Using flow cytometry, monocyte subset percentages were evaluated before, immediately after, and 1 hour after 45 minutes of acute, intermittent exercise. Exercise intensity was 60% of peak wattage obtained from a cardiopulmonary exercise test.
Results: The percentage of CD14+ monocytes and CD14+CD16- monocyte subsets changed significantly across the trial (p= 0.016 and p = 0.016, respectively), with a small, non-significant increase immediately after exercise (CD14+: 9%, p= 0.314; CD14+CD16-: 5%, p= 0.594) followed by a larger significant decrease 1 hour after exercise relative to baseline (CD14+: -26%, p= 0.015; CD14+CD16-: -28%, p= 0.021). CD14+CD16+ subpopulation showed a tendency to change across the trial but this did not quite reach significance (p= 0.097).
Conclusion: These findings suggest that acute intermittent exercise mobilizes CD14+ monocytes and CD14+CD16- monocyte subsets in breast cancer survivors in a manner that is comparable to previous reports in healthy individuals. Further studies are warranted to determine the functionality of the mobilized monocytes and the effects of exercise training.
Methods: Ten breast cancer survivors (age: 59 ± 7.1) who completed their primary cancer treatment within the previous year were evaluated in this study. Using flow cytometry, monocyte subset percentages were evaluated before, immediately after, and 1 hour after 45 minutes of acute, intermittent exercise. Exercise intensity was 60% of peak wattage obtained from a cardiopulmonary exercise test.
Results: The percentage of CD14+ monocytes and CD14+CD16- monocyte subsets changed significantly across the trial (p= 0.016 and p = 0.016, respectively), with a small, non-significant increase immediately after exercise (CD14+: 9%, p= 0.314; CD14+CD16-: 5%, p= 0.594) followed by a larger significant decrease 1 hour after exercise relative to baseline (CD14+: -26%, p= 0.015; CD14+CD16-: -28%, p= 0.021). CD14+CD16+ subpopulation showed a tendency to change across the trial but this did not quite reach significance (p= 0.097).
Conclusion: These findings suggest that acute intermittent exercise mobilizes CD14+ monocytes and CD14+CD16- monocyte subsets in breast cancer survivors in a manner that is comparable to previous reports in healthy individuals. Further studies are warranted to determine the functionality of the mobilized monocytes and the effects of exercise training.
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These findings suggest that acute intermittent exercise mobilizes CD14+ monocytes and CD14+CD16- monocyte subsets in breast cancer survivors in a manner that is comparable to previous reports in healthy individuals. Further studies are warranted to determine the functionality of the mobilized monocytes and the effects of exercise training
Type of Study: Research |
Subject:
Breast Diseases
Received: 2018/02/26 | Accepted: 2018/06/26 | Published: 2018/06/26
Received: 2018/02/26 | Accepted: 2018/06/26 | Published: 2018/06/26
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