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Volume 18, Issue 1 (Iranian Journal of Breast Diseases 2025)
ijbd 2025, 18(1): 47-61 |
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Ethics code: 1547/EC/KEPK-RSDK/2023
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Cahya G D, Harahap M S, Rachmawati B, Nurcahyo W I, Prajoko Y W. The effect of breast cancer surgery on inflammatory response: important role of interleukin-6 and platelet-to-lymphocyte ratio in breast cancer surgery. ijbd 2025; 18 (1) :47-61
URL: http://ijbd.ir/article-1-1139-en.html
URL: http://ijbd.ir/article-1-1139-en.html
Gani Dwi Cahya1 
, Mohamad Sofyan Harahap2 , Banundari Rachmawati3 , Widya Istanto Nurcahyo3 , Yan Wisnu Prajoko *4
, Mohamad Sofyan Harahap2 , Banundari Rachmawati3 , Widya Istanto Nurcahyo3 , Yan Wisnu Prajoko *4
1- Department of Surgery, Dr. Kariadi Hospital-Diponegoro University, Semarang, Indonesia
2- Department of Anesthesiology, Dr. Kariadi Hospital-Diponegoro University, Semarang, Indonesia
3- Department of Clinical Pathology, Dr. Kariadi Hospital-Diponegoro University, Semarang, Indonesia
4- Department of Oncology Surgery, Dr. Kariadi Hospital-Diponegoro University, Semarang, Indonesia ,yanprajoko7519@gmail.com
2- Department of Anesthesiology, Dr. Kariadi Hospital-Diponegoro University, Semarang, Indonesia
3- Department of Clinical Pathology, Dr. Kariadi Hospital-Diponegoro University, Semarang, Indonesia
4- Department of Oncology Surgery, Dr. Kariadi Hospital-Diponegoro University, Semarang, Indonesia ,
Abstract: (510 Views)
Background: Cancer is the world’s second leading cause of death, where 48,998 new breast cancer cases were found everyyear in Indonesia. Surgery procedure as primary treatment for breast cancer induced inflammation and immunosuppression, releasing inflammatory cytokines namely IL-6 and Platelet-To-Lymphocyte Ratio (PLR) as proinflammatory mediator. Pectoralis Nerve (PECS) II combination with general anesthesia (GA) is a common anesthetic technique in breast cancer surgery. Research about PECS Block and GA effect on proinflammatory biomarkers in early breast cancer surgery is still limited. This research aims to study the effects of the GA and PECS II combination compared to GA alone on IL-6 and PLR in breast cancer patients undergoing breast removal surgery.
Method: This is an experimental study with pre-post test randomized control group design. 48 breast cancer patients who underwent breast removal surgery who meet the research criteria were included in this research. IL-6 and PLR were taken from blood sample 24 hour before and after surgery.
Results: Postoperative IL-6 levels were higher in GA group (11,18 ± 6,81) compared with PECS block (10,43 ± 9,40). Postoperative PLR levels were higher in GA group (268,79 ± 208,48) than PECS block (160,91 ± 62,58). The difference between IL-6 and PLR levels was found to be higher in GA group (2,35 ± 3,54 and 54,13 ± 110,61).
Conclusion: IL-6 and PLR as inflammation biomarkers were found to be lower in combination of PECS block II with GA than in GA alone.
Method: This is an experimental study with pre-post test randomized control group design. 48 breast cancer patients who underwent breast removal surgery who meet the research criteria were included in this research. IL-6 and PLR were taken from blood sample 24 hour before and after surgery.
Results: Postoperative IL-6 levels were higher in GA group (11,18 ± 6,81) compared with PECS block (10,43 ± 9,40). Postoperative PLR levels were higher in GA group (268,79 ± 208,48) than PECS block (160,91 ± 62,58). The difference between IL-6 and PLR levels was found to be higher in GA group (2,35 ± 3,54 and 54,13 ± 110,61).
Conclusion: IL-6 and PLR as inflammation biomarkers were found to be lower in combination of PECS block II with GA than in GA alone.
Type of Study: Research |
Subject:
Diagnosis, treatment, rehabilitation
Received: 2024/09/23 | Accepted: 2024/12/7 | Published: 2025/03/19
Received: 2024/09/23 | Accepted: 2024/12/7 | Published: 2025/03/19
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